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GPCR

NameGastric inhibitory polypeptide receptor
SpeciesHomo sapiens (Human)
GeneGIPR
SynonymGIP-R
GIP receptor
Glucose-dependent insulinotropic polypeptide receptor
Gippr
DiseaseType 2 diabetes
Length466
Amino acid sequenceMTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPPSGLACNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQWGLWRDHTQCENPEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHINLFTSFMLRAAAILSRDRLLPRPGPYLGDQALALWNQALAACRTAQIVTQYCVGANYTWLLVEGVYLHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKAIWWIIRTPILMTILINFLIFIRILGILLSKLRTRQMRCRDYRLRLARSTLTLVPLLGVHEVVFAPVTEEQARGALRFAKLGFEIFLSSFQGFLVSVLYCFINKEVQSEIRRGWHHCRLRRSLGEEQRQLPERAFRALPSGSGPGEVPTSRGLSSGTLPGPGNEASRELESYC
UniProtP48546
Protein Data BankN/A
GPCR-HGmod modelP48546
3D structure modelThis predicted structure model is from GPCR-EXP P48546.
BioLiPN/A
Therapeutic Target DatabaseT41750
ChEMBLCHEMBL4383
IUPHAR248
DrugBankN/A

Ligand

Nameaminothiazole, 12
Molecular formulaC31H30F3N3O3S
IUPAC name3-[[4-[(3-methyl-4-propan-2-yl-N-[4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]anilino)methyl]benzoyl]amino]propanoic acid
Molecular weight581.654
Hydrogen bond acceptor9
Hydrogen bond donor2
XlogP7.3
SynonymsCHEMBL523847
BDBM29115
SCHEMBL2654594
Inchi KeyMYYKZRMEYNXGOG-UHFFFAOYSA-N
Inchi IDInChI=1S/C31H30F3N3O3S/c1-19(2)26-13-12-25(16-20(26)3)37(17-21-4-6-23(7-5-21)29(40)35-15-14-28(38)39)30-36-27(18-41-30)22-8-10-24(11-9-22)31(32,33)34/h4-13,16,18-19H,14-15,17H2,1-3H3,(H,35,40)(H,38,39)
PubChem CID22496557
ChEMBLCHEMBL523847
IUPHARN/A
BindingDB29115
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC50293.0 nMPMID19385613ChEMBL
IC50633.0 nMPMID19385613BindingDB,ChEMBL

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