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GPCR

NameTrace amine-associated receptor 7b
SpeciesRattus norvegicus (Rat)
GeneTaar7b
SynonymTaR-12
Trace amine receptor 12
Trace amine receptor 7b
TaR-7b
DiseaseN/A for non-human GPCRs
Length358
Amino acid sequenceMATDDDRFPWDQDSILSRDLLSASSMQLCYEKLNRSCVRSPYSPGPRLILYAVFGFGAVLAVCGNLLVMTSILHFRQLHSPANFLVASLACADFLVGLTVMPFSMVRSVEGCWYFGDIYCKFHSSFDGSFCYSSIFHLCFISADRYIAVSDPLIYPTRFTASVSGKCITFSWLLSIIYSFSLFYTGVNEAGLEDLVSALTCVGGCQIAVNQSWVFINFLLFLVPALVMMTVYSKIFLIAKQQAQNIEKMGKQTARASESYKDRVAKRERKAAKTLGIAVAAFLLSWLPYFIDSIIDAFLGFVTPTYVYEILVWIGYYNSAMNPLIYAFFYPWFRKAIKLIVTGKILRENSSATNLFPE
UniProtQ923X8
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2176813
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3701903
Molecular formulaC21H24ClF3N2
IUPAC nameN-[1-(4-chlorophenyl)-2,2,2-trifluoroethyl]-4-(2-piperidin-3-ylethyl)aniline
Molecular weight396.882
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP6.1
SynonymsSCHEMBL12609930
BDBM129362
US8802673, 4
Inchi KeyBEOYESMOQLVWGJ-UHFFFAOYSA-N
Inchi IDInChI=1S/C21H24ClF3N2/c22-18-9-7-17(8-10-18)20(21(23,24)25)27-19-11-5-15(6-12-19)3-4-16-2-1-13-26-14-16/h5-12,16,20,26-27H,1-4,13-14H2
PubChem CID68325662
ChEMBLCHEMBL3701903
IUPHARN/A
BindingDB129362
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Ki78.5 nM, NoneBindingDB,ChEMBL

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