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Name | 5-hydroxytryptamine receptor 4 |
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Species | Rattus norvegicus (Rat) |
Gene | Htr4 |
Synonym | 5-HT-4 5-HT4 5-HT4 receptor 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled serotonin receptor 4 |
Disease | N/A for non-human GPCRs |
Length | 406 |
Amino acid sequence | MDRLDANVSSNEGFGSVEKVVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVNAFGAIELVQDIWFYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIEKRKFNHNSNSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRPQTADQHSTHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYKRPPILGQTVPCSTTTINGSTHVLRDTVECGGQWESRCHLTATSPLVAAQPVIRRPQDNDLEDSCSLKRSQS |
UniProt | Q62758 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4317 |
IUPHAR | 9 |
DrugBank | N/A |
Name | CHEMBL62023 |
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Molecular formula | C18H24N4O2 |
IUPAC name | 3-ethyl-N-(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)-2-oxobenzimidazole-1-carboxamide |
Molecular weight | 328.416 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 1 |
XlogP | 2.1 |
Synonyms | Bimu 1 3-Ethyl-2-oxo-2,3-dihydro-benzoimidazole-1-carboxylic acid (8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-amide; hydrochloride AC1L2YB7 PDSP2_001654 CHEMBL544755 [ Show all ] |
Inchi Key | MZRKHUUDDHJVHS-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C18H24N4O2/c1-3-21-15-6-4-5-7-16(15)22(18(21)24)17(23)19-12-10-13-8-9-14(11-12)20(13)2/h4-7,12-14H,3,8-11H2,1-2H3,(H,19,23) |
PubChem CID | 130946 |
ChEMBL | CHEMBL62023 |
IUPHAR | N/A |
BindingDB | 50007872 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 10.0 nM | , Bioorg. Med. Chem. Lett., (1993) 3:4:633 | BindingDB,ChEMBL |
Intrinsic activity | 0.7 - | Bioorg. Med. Chem. Lett., (1993) 3:4:633 | ChEMBL |
Ki | 0.19 nM | PMID8584042 | BindingDB |
Relaxation | 37.5 % | PMID9599243 | ChEMBL |
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