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Name | Alpha-2A adrenergic receptor |
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Species | Homo sapiens (Human) |
Gene | ADRA2A |
Synonym | alpha2D alpha2A-AR alpha2A-adrenoceptor alpha2A-adrenergic receptor alpha2A [ Show all ] |
Disease | Attention deficit hyperactivity disorder Sexual dysfunction Pain |
Length | 450 |
Amino acid sequence | MGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAVAAPPGGTERRPNGLGPERSAGPGGAEAEPLPTQLNGAPGEPAPAGPRDTDALDLEESSSSDHAERPPGPRRPERGPRGKGKARASQVKPGDSLPRRGPGATGIGTPAAGPGEERVGAAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV |
UniProt | P08913 |
Protein Data Bank | N/A |
GPCR-HGmod model | P08913 |
3D structure model | This predicted structure model is from GPCR-EXP P08913. |
BioLiP | N/A |
Therapeutic Target Database | T11448 |
ChEMBL | CHEMBL1867 |
IUPHAR | 25 |
DrugBank | BE0000289 |
Name | AGN 192836 |
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Molecular formula | C12H13N3O2 |
IUPAC name | N-(5-methyl-2,3-dihydro-1,4-benzodioxin-6-yl)-1H-imidazol-2-amine |
Molecular weight | 231.255 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 2 |
XlogP | 2.0 |
Synonyms | 2-[[(5-Methyl-2,3-dihydro-1,4-benzodioxin)-6-yl]amino]-1H-imidazole HY-100300 AGN192836 (1H-Imidazol-2-yl)-(5-methyl-2,3-dihydro-benzo[1,4]dioxin-6-yl)-amine CHEMBL308570 [ Show all ] |
Inchi Key | NDFYRGCPDAFQDG-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C12H13N3O2/c1-8-9(15-12-13-4-5-14-12)2-3-10-11(8)17-7-6-16-10/h2-5H,6-7H2,1H3,(H2,13,14,15) |
PubChem CID | 10176999 |
ChEMBL | CHEMBL308570 |
IUPHAR | N/A |
BindingDB | 50055832 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 8.7 nM | PMID9016324 | BindingDB,ChEMBL |
IA | 0.89 - | PMID9016324 | ChEMBL |
Ki | 1.7 nM | PMID9016324 | BindingDB,ChEMBL |
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