Home Research COVID-19 Services Publications People Teaching Job Opening News Forum Lab Only
Online Services

I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK LOMETS MUSTER CEthreader SEGMER DeepFold DeepFoldRNA FoldDesign COFACTOR COACH MetaGO TripletGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner GPU-I-TASSER

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

You can:

GPCR

NameGastric inhibitory polypeptide receptor
SpeciesHomo sapiens (Human)
GeneGIPR
SynonymGIP-R
GIP receptor
Glucose-dependent insulinotropic polypeptide receptor
Gippr
DiseaseType 2 diabetes
Length466
Amino acid sequenceMTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPPSGLACNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQWGLWRDHTQCENPEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHINLFTSFMLRAAAILSRDRLLPRPGPYLGDQALALWNQALAACRTAQIVTQYCVGANYTWLLVEGVYLHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKAIWWIIRTPILMTILINFLIFIRILGILLSKLRTRQMRCRDYRLRLARSTLTLVPLLGVHEVVFAPVTEEQARGALRFAKLGFEIFLSSFQGFLVSVLYCFINKEVQSEIRRGWHHCRLRRSLGEEQRQLPERAFRALPSGSGPGEVPTSRGLSSGTLPGPGNEASRELESYC
UniProtP48546
Protein Data BankN/A
GPCR-HGmod modelP48546
3D structure modelThis predicted structure model is from GPCR-EXP P48546.
BioLiPN/A
Therapeutic Target DatabaseT41750
ChEMBLCHEMBL4383
IUPHAR248
DrugBankN/A

Ligand

NameCHEMBL1644201
Molecular formulaC26H17F6N7O3
IUPAC name3-[[3,5-bis[4-(trifluoromethoxy)phenyl]pyrazol-1-yl]methyl]-N-(2H-tetrazol-5-yl)benzamide
Molecular weight589.458
Hydrogen bond acceptor13
Hydrogen bond donor2
XlogP6.2
SynonymsBDBM50334513
SCHEMBL9071571
3-((3,5-bis(4-(trifluoromethoxy)phenyl)-1H-pyrazol-1-yl)methyl)-N-(2H-tetrazol-5-yl)benzamide
Inchi KeyNEHBDABNFNVIPZ-UHFFFAOYSA-N
Inchi IDInChI=1S/C26H17F6N7O3/c27-25(28,29)41-19-8-4-16(5-9-19)21-13-22(17-6-10-20(11-7-17)42-26(30,31)32)39(36-21)14-15-2-1-3-18(12-15)23(40)33-24-34-37-38-35-24/h1-13H,14H2,(H2,33,34,35,37,38,40)
PubChem CID53321835
ChEMBLCHEMBL1644201
IUPHARN/A
BindingDB50334513
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Inhibition2.0 %PMID21147532ChEMBL

zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218