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GPCR

NameD(2) dopamine receptor
SpeciesCanis lupus familiaris (Dog)
GeneDRD2
SynonymDopamine D2 receptor
DiseaseN/A for non-human GPCRs
Length443
Amino acid sequenceMDPLNLSWYDDDLESQNWSRPFNGSEGKPGKPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTERSSRAFRANLKAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTADSPAKPEKNGHAKDHPKIAKIFEIQSMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCECNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
UniProtQ9GJU1
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2703
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL41833
Molecular formulaC17H24ClN3O2
IUPAC name8-amino-7-chloro-4-[2-(diethylamino)ethyl]-2,3-dimethyl-1,4-benzoxazepin-5-one
Molecular weight337.848
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP2.6
Synonyms8-Amino-7-chloro-4-(2-diethylamino-ethyl)-2,3-dimethyl-4H-benzo[f][1,4]oxazepin-5-one
BDBM50023863
Inchi KeyNGKKXOWMANWJNE-UHFFFAOYSA-N
Inchi IDInChI=1S/C17H24ClN3O2/c1-5-20(6-2)7-8-21-11(3)12(4)23-16-10-15(19)14(18)9-13(16)17(21)22/h9-10H,5-8,19H2,1-4H3
PubChem CID14116961
ChEMBLCHEMBL41833
IUPHARN/A
BindingDB50023863
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
ED50<3.0 mg.kg-1PMID3397992ChEMBL

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