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GPCR

Name	Somatostatin receptor type 2
Species	Mus musculus (Mouse)
Gene	Sstr2
Synonym	somatotropin release-inhibiting factor receptor SRIF-1 SS-2-R SS2-R SS2R SST2 receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	369
Amino acid sequence	MEMSSEQLNGSQVWVSSPFDLNGSLGPSNGSNQTEPYYDMTSNAVLTFIYFVVCVVGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMINVAVWCVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYAFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSVAISPTPALKGMFDFVVILTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTEDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI
UniProt	P30875
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3207
IUPHAR	356
DrugBank	N/A

Ligand

Name	SOMATOSTATIN
Molecular formula	C76H104N18O19S2
IUPAC name	(4R,7S,10S,13S,16S,19S,22S,25S,28S,31S,34S,37R)-19,34-bis(4-aminobutyl)-31-(2-amino-2-oxoethyl)-37-[[2-[[(2S)-2-aminopropanoyl]amino]acetyl]amino]-13,25,28-tribenzyl-10,16-bis[(1R)-1-hydroxyethyl]-7-(hydroxymethyl)-22-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24,27,30,33,36-undecaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35-undecazacyclooctatriacontane-4-carboxylic acid
Molecular weight	1637.9
Hydrogen bond acceptor	24
Hydrogen bond donor	22
XlogP	-3.1
Synonyms	55914-64-2 BRD-K14681867-015-01-6 Cyclic Somatostatin H664 NHXLMOGPVYXJNR-ATOGVRKGSA-N Somatostatin [INN:BAN] Somatostatinum UNII-6E20216Q0L 916S346 CB6417646 EINECS 254-186-5 L-alanylglycyl-L-cysteinyl-L-lysyl-L-asparaginyl-L-phenylalanyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-cysteine cyclic (3-14) disulfide Somatostatin (pigeon) Somatostatin-14 SR 9357 51110-01-1 (Parent) Ala-Gly-cyclo-[Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys] Growth hormone-release inhibiting factor: L-alanylglycyl-L-cysteinyl-L-lysyl-L-asparaginyl-L-phenylalanyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-cysteine cyclic (3-14) disulfide MolPort-006-823-896 Somatostatin acetate Somatostatine Synthetic growth hormone release-inhibiting hormone 6E20216Q0L C76H104N18O19S2 D0T5RO HS-2027 Somatostatin, cyclic Somatostatinum [INN-Latin] UNII-F6R2N217HS AK552885 CCRIS 3629 F6R2N217HS LS-174755 Somatostatin (rat) Somatostatina SRIF 15-28-Somatostatin-28 52769-04-7 BDBM81767 CHEMBL1823872 Growth hormone-release inhibiting factor: L-alanylglycyl-L-cysteinyl-L-lysyl-L-asparaginyl-L-phenylalanyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-cysteine cyclic (3->14) disulfide NCGC00167137-01 Somatostatin [BAN:INN] Somatostatine [INN-French] Synthetic somatostatin-14 CAS_38916-34-6 L-alanyl-N-[(4R,7S,10S,13S,16S,19S,22S,25S,28S,31S,34S,37R)-19,34-bis(4-aminobutyl)-31-(2-amino-2-oxoethyl)-13,25,28-tribenzyl-4-carboxy-10,16-bis[(1R)-1-hydroxyethyl]-7-(hydroxymethyl)-22-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24,27,30,33,36-undecaoxo-1,2 Somatostatin (human) Somatostatin-1 Somatotropin release inhibiting factor AKOS015994634 CHEBI:64628 Growth hormone release inhibiting factor MFCD00076762 Somatostatin (sheep) Somatostatina [INN-Spanish] Synthetic cyclic growth hormone release-inhibiting factor 38916-34-6 [ Show all ]
Inchi Key	NHXLMOGPVYXJNR-ATOGVRKGSA-N
Inchi ID	InChI=1S/C76H104N18O19S2/c1-41(79)64(100)82-37-61(99)83-58-39-114-115-40-59(76(112)113)92-72(108)57(38-95)91-75(111)63(43(3)97)94-71(107)54(33-46-23-11-6-12-24-46)90-74(110)62(42(2)96)93-66(102)51(28-16-18-30-78)84-69(105)55(34-47-36-81-49-26-14-13-25-48(47)49)88-68(104)53(32-45-21-9-5-10-22-45)86-67(103)52(31-44-19-7-4-8-20-44)87-70(106)56(35-60(80)98)89-65(101)50(85-73(58)109)27-15-17-29-77/h4-14,19-26,36,41-43,50-59,62-63,81,95-97H,15-18,27-35,37-40,77-79H2,1-3H3,(H2,80,98)(H,82,100)(H,83,99)(H,84,105)(H,85,109)(H,86,103)(H,87,106)(H,88,104)(H,89,101)(H,90,110)(H,91,111)(H,92,108)(H,93,102)(H,94,107)(H,112,113)/t41-,42+,43+,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,62-,63-/m0/s1
PubChem CID	16129706
ChEMBL	CHEMBL1823872
IUPHAR	N/A
BindingDB	81767
DrugBank	DB09099
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	0.28 nM	PMID9216843	ChEMBL
IC50	0.28 nM	PMID9216843	BindingDB
Ki	0.08 nM	PMID1328199	BindingDB
Ki	0.23 nM	PMID9600011	BindingDB
Ki	0.28 nM	PMID8100350, PMID7870182	BindingDB
Ki	1.43 nM	PMID9600011	BindingDB

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