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GPCR

NameGlucagon-like peptide 1 receptor
SpeciesHomo sapiens (Human)
GeneGLP1R
SynonymGLP-1-R
GLP-1 receptor
glucagon-like peptide 1 receptor
GLP-1R
DiseaseNon-insulin dependent diabetes
Type 2 diabetes
Type 1/2 diabetes
Type 1 diabetes
Obesity
[ Show all ]
Length463
Amino acid sequenceMAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProtP43220
Protein Data Bank5vew, 5otv, 3c5t, 4zgm, 3iol, 5otu, 5vex, 5otw, 5otx, 3c59, 5nx2
GPCR-HGmod modelP43220
3D structure modelThis structure is from PDB ID 5vew.
BioLiPBL0418500,BL0418501, BL0418494,BL0418495, BL0380967, BL0143732, BL0143731, BL0379513,BL0379514, BL0418496,BL0418497, BL0143795, BL0143794, BL0378791,BL0378792, BL0167480, BL0167479, BL0324355,BL0324356, BL0418498,BL0418499, BL0324354, BL0380966
Therapeutic Target DatabaseT36075
ChEMBLCHEMBL1784
IUPHAR249
DrugBankBE0000857

Ligand

Name2-(1H-indol-3-yl)-N-(3-(4-(4-methoxyphenyl)piperazin-1-yl)propyl)-2-oxoacetamide
Molecular formulaC24H28N4O3
IUPAC name2-(1H-indol-3-yl)-N-[3-[4-(4-methoxyphenyl)piperazin-1-yl]propyl]-2-oxoacetamide
Molecular weight420.513
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP3.2
Synonyms2-(1H-indol-3-yl)-N-[3-[4-(4-methoxyphenyl)piperazin-1-yl]propyl]-2-oxoacetamide
AC1OETPW
MLS001167312
CHEMBL1702231
MolPort-001-684-624
[ Show all ]
Inchi KeyADFVWRXTQPTXFD-UHFFFAOYSA-N
Inchi IDInChI=1S/C24H28N4O3/c1-31-19-9-7-18(8-10-19)28-15-13-27(14-16-28)12-4-11-25-24(30)23(29)21-17-26-22-6-3-2-5-20(21)22/h2-3,5-10,17,26H,4,11-16H2,1H3,(H,25,30)
PubChem CID7087103
ChEMBLCHEMBL1702231
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Potency22387.2 nMPubChem BioAssay data setChEMBL

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