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GPCR

NameNociceptin receptor
SpeciesMus musculus (Mouse)
GeneOprl1
SynonymNOP receptor
NOP-r
NOPr
OP4
ORGC
[ Show all ]
DiseaseN/A for non-human GPCRs
Length367
Amino acid sequenceMESLFPAPFWEVLYGSHFQGNLSLLNETVPHHLLLNASHSAFLPLGLKVTIVGLYLAVCIGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPAPQDYWGPVFAICIFLFSFIIPVLIISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLVQGLGVQPGSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALHREMQVSDRVRSIAKDVGLGCKTSETVPRPA
UniProtP35377
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3621
IUPHAR320
DrugBankN/A

Ligand

NameCHEMBL412606
Molecular formulaC61H100N22O16
IUPAC name(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-2-[[2-[[(2S,3R)-3-hydroxy-2-[[(2S)-2-[[2-[[2-[[2-[(4-hydroxyphenyl)methylamino]acetyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]butanoyl]amino]acetyl]amino]propanoyl]amino]pentanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
Molecular weight1397.61
Hydrogen bond acceptor21
Hydrogen bond donor23
XlogP-7.3
SynonymsN/A
Inchi KeyNIBCKHVOTZAIJD-DNZAOUQTSA-N
Inchi IDInChI=1S/C61H100N22O16/c1-34(75-48(89)32-74-59(99)50(36(3)85)83-57(97)44(27-37-13-5-4-6-14-37)77-49(90)31-73-47(88)30-72-46(87)29-69-28-38-19-21-39(86)22-20-38)52(92)79-43(18-12-26-71-61(67)68)55(95)81-41(16-8-10-24-63)56(96)82-45(33-84)58(98)76-35(2)53(93)80-42(17-11-25-70-60(65)66)54(94)78-40(51(64)91)15-7-9-23-62/h4-6,13-14,19-22,34-36,40-45,50,69,84-86H,7-12,15-18,23-33,62-63H2,1-3H3,(H2,64,91)(H,72,87)(H,73,88)(H,74,99)(H,75,89)(H,76,98)(H,77,90)(H,78,94)(H,79,92)(H,80,93)(H,81,95)(H,82,96)(H,83,97)(H4,65,66,70)(H4,67,68,71)/t34-,35-,36+,40-,41-,42-,43-,44-,45-,50-/m0/s1
PubChem CID10701675
ChEMBLCHEMBL412606
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Ki3162.28 nMPMID10956188ChEMBL

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