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GPCR

NameAlpha-1D adrenergic receptor
SpeciesHomo sapiens (Human)
GeneADRA1D
Synonymalpha1a/d-adrenoceptor
adrenergic receptor delta1
Gpcr8
Adrd1
ADRA1R
[ Show all ]
DiseaseUrinary incontinence
Benign prostatic hyperplasia
Congestive heart failure
Diabetes
Erectile dysfunction
[ Show all ]
Length572
Amino acid sequenceMTFRDLLSVSFEGPRPDSSAGGSSAGGGGGSAGGAAPSEGPAVGGVPGGAGGGGGVVGAGSGEDNRSSAGEPGSAGAGGDVNGTAAVGGLVVSAQGVGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVALVVSVGPLLGWKEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRRPLWRVYGHHWRASTSGLRQDCAPSSGDAPPGAPLALTALPDPDPEPPGTPEMQAPVASRRKPPSAFREWRLLGPFRRPTTQLRAKVSSLSHKIRAGGAQRAEAACAQRSEVEAVSLGVPHEVAEGATCQAYELADYSNLRETDI
UniProtP25100
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseT53381
ChEMBLCHEMBL223
IUPHAR24
DrugBankBE0004863, BE0000715

Ligand

NameCHEMBL75808
Molecular formulaC24H34N6O2
IUPAC name1-[[2-amino-6-[[4-(2-propan-2-yloxyphenyl)piperazin-1-yl]methyl]pyrimidin-4-yl]methyl]piperidin-2-one
Molecular weight438.576
Hydrogen bond acceptor7
Hydrogen bond donor1
XlogP1.8
Synonyms1-[2-Amino-6-[4-(2-isopropoxyphenyl)piperazinomethyl]-4-pyrimidinylmethyl]piperidine-2-one
BDBM50093218
1-{2-Amino-6-[4-(2-isopropoxy-phenyl)-piperazin-1-ylmethyl]-pyrimidin-4-ylmethyl}-piperidin-2-one
Inchi KeyBFLQALILHDTZOK-UHFFFAOYSA-N
Inchi IDInChI=1S/C24H34N6O2/c1-18(2)32-22-8-4-3-7-21(22)29-13-11-28(12-14-29)16-19-15-20(27-24(25)26-19)17-30-10-6-5-9-23(30)31/h3-4,7-8,15,18H,5-6,9-14,16-17H2,1-2H3,(H2,25,26,27)
PubChem CID12134985
ChEMBLCHEMBL75808
IUPHARN/A
BindingDB50093218
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki<10000.0 nMPMID11055359BindingDB,ChEMBL

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