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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Endothelin receptor type B
Species	Mus musculus (Mouse)
Gene	Ednrb
Synonym	endothelin B receptor Endothelin receptor non-selective type ET-B ET-BR ETB receptor HSCR HSCR2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	442
Amino acid sequence	MQSPASRCGRALVALLLACGFLGVWGEKRGFPPAQATLSLLGTKEVMTPPTKTSWTRGSNSSLMRSSAPAEVTKGGRGAGVPPRSFPPPCQRNIEISKTFKYINTIVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINTYKLLAEDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDMITSDYKGKPLRVCMLNPFQKTAFMQFYKTAKDWWLFSFYFCLPLAITAVFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYDQSNPHRCELLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQTFEEKQSLEEKQSCLKFKANDHGYDNFRSSNKYSSS
UniProt	P48302
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1681617
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL1672880
Molecular formula	C35H39FO12
IUPAC name	3-(1,3-benzodioxol-5-yl)-4-[[3-[2-[2-[2-(2-fluoroethoxy)ethoxy]ethoxy]ethoxy]-4,5-dimethoxyphenyl]methyl]-5-hydroxy-5-(4-methoxyphenyl)furan-2-one
Molecular weight	670.683
Hydrogen bond acceptor	13
Hydrogen bond donor	1
XlogP	3.9
Synonyms	BDBM50336694 3-Benzo[1,3]dioxol-5-yl-4-{3-(2-(2-(2-(2-fluoroethoxy)ethoxy)-ethoxy)ethoxy)-4,5-dimethoxybenzyl}-5-hydroxy-5-(4-methoxyphenyl)-5H-furan-2-one
Inchi Key	NKOJYTIBYBSFJN-UHFFFAOYSA-N
Inchi ID	InChI=1S/C35H39FO12/c1-39-26-7-5-25(6-8-26)35(38)27(32(34(37)48-35)24-4-9-28-29(21-24)47-22-46-28)18-23-19-30(40-2)33(41-3)31(20-23)45-17-16-44-15-14-43-13-12-42-11-10-36/h4-9,19-21,38H,10-18,22H2,1-3H3
PubChem CID	51003306
ChEMBL	CHEMBL1672880
IUPHAR	N/A
BindingDB	50336694
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Ki	418.0 nM	PMID21275367	BindingDB,ChEMBL

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