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Name | Endothelin-1 receptor |
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Species | Mus musculus (Mouse) |
Gene | Ednra |
Synonym | ETA receptor ET-AR ET-A endothelin-1 receptor Endothelin receptor type A {ECO:0000312|MGI:MGI:105923} [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 427 |
Amino acid sequence | MSIFCLAAYFWLTMVGGVMADNPERYSANLSSHMEDFTPFPGTEINFLGTTHRPPNLALPSNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGELHRTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNNHNTERSSHKDSMN |
UniProt | Q61614 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL2286 |
IUPHAR | N/A |
DrugBank | N/A |
Name | CHEMBL1672880 |
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Molecular formula | C35H39FO12 |
IUPAC name | 3-(1,3-benzodioxol-5-yl)-4-[[3-[2-[2-[2-(2-fluoroethoxy)ethoxy]ethoxy]ethoxy]-4,5-dimethoxyphenyl]methyl]-5-hydroxy-5-(4-methoxyphenyl)furan-2-one |
Molecular weight | 670.683 |
Hydrogen bond acceptor | 13 |
Hydrogen bond donor | 1 |
XlogP | 3.9 |
Synonyms | 3-Benzo[1,3]dioxol-5-yl-4-{3-(2-(2-(2-(2-fluoroethoxy)ethoxy)-ethoxy)ethoxy)-4,5-dimethoxybenzyl}-5-hydroxy-5-(4-methoxyphenyl)-5H-furan-2-one BDBM50336694 |
Inchi Key | NKOJYTIBYBSFJN-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C35H39FO12/c1-39-26-7-5-25(6-8-26)35(38)27(32(34(37)48-35)24-4-9-28-29(21-24)47-22-46-28)18-23-19-30(40-2)33(41-3)31(20-23)45-17-16-44-15-14-43-13-12-42-11-10-36/h4-9,19-21,38H,10-18,22H2,1-3H3 |
PubChem CID | 51003306 |
ChEMBL | CHEMBL1672880 |
IUPHAR | N/A |
BindingDB | 50336694 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 1.4 nM | PMID21275367 | BindingDB,ChEMBL |
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