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GPCR

Name5-hydroxytryptamine receptor 1D
SpeciesSus scrofa (Pig)
GeneHTR1D
Synonym5-HT-1D
5-HT1D
Serotonin receptor 1D
DiseaseN/A for non-human GPCRs
Length291
Amino acid sequenceAMTDLLVSILVMPISIPYTITQTWSFGQLLCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAIVWAISICISIPPLFWRQARAHEEISDCLVNTSQISYTIYSTCGAFYIPSLLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNPSLHEGHSHSAGSPLFFNHVKIKLADSVLERKRISAARERKATKTLGIILGAFIICWLPFFVASLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKVV
UniProtP79400
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4105
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL415933
Molecular formulaC23H28N6O
IUPAC name7-methoxy-4-[4-(4-pyrazol-1-ylbutyl)piperazin-1-yl]pyrrolo[1,2-a]quinoxaline
Molecular weight404.518
Hydrogen bond acceptor5
Hydrogen bond donor0
XlogP3.7
SynonymsBDBM50408150
Inchi KeyNOIZELMBLJHYSX-UHFFFAOYSA-N
Inchi IDInChI=1S/C23H28N6O/c1-30-19-7-8-21-20(18-19)25-23(22-6-4-13-29(21)22)27-16-14-26(15-17-27)10-2-3-11-28-12-5-9-24-28/h4-9,12-13,18H,2-3,10-11,14-17H2,1H3
PubChem CID44296810
ChEMBLCHEMBL415933
IUPHARN/A
BindingDB50408150
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50<100000.0 nMPMID9191957BindingDB,ChEMBL

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