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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Neuropeptide Y receptor type 5
Species	Mus musculus (Mouse)
Gene	Npy5r
Synonym	food intake receptor neuropeptide Y receptor type 5 NPY-Y5 receptor NPY5-R NPYY5-R Y5 receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	466
Amino acid sequence	MEVKLEEHFNKTFVTENNTAASQNTASPAWEDYRGTENNTSAARNTAFPVWEDYRGSVDDLQYFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKETFGSALLSSKYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSHKENRLEENEMINLTLHPSKKSRDQAKPPSTQKWSYSFIRKHRRRYSKKTACVLPAPAGPSQEKHLTVPENPGSVRSQLSPSSKVIPGVPICFEVKPEESSDAQEMRVKRSLTRIKKRSRSVFYRLTILILVFAVSWMPLHVFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLRALIHCLHMS
UniProt	O70342
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3802
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL1956849
Molecular formula	C21H25N3O4S
IUPAC name	N-[4-[(2S,6R)-2,6-dimethylmorpholin-4-yl]phenyl]-5-ethylsulfonyl-1,3-benzoxazol-2-amine
Molecular weight	415.508
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	3.9
Synonyms	BDBM50365397
Inchi Key	NOLDAOWZNAVPJE-GASCZTMLSA-N
Inchi ID	InChI=1S/C21H25N3O4S/c1-4-29(25,26)18-9-10-20-19(11-18)23-21(28-20)22-16-5-7-17(8-6-16)24-12-14(2)27-15(3)13-24/h5-11,14-15H,4,12-13H2,1-3H3,(H,22,23)/t14-,15+
PubChem CID	57328464
ChEMBL	CHEMBL1956849
IUPHAR	N/A
BindingDB	50365397
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	71.0 nM	PMID22300657	BindingDB,ChEMBL

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