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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Prostaglandin E2 receptor EP1 subtype
Species	Rattus norvegicus (Rat)
Gene	Ptger1
Synonym	EP1 prostanoid receptor EP1 receptor PGE receptor EP1 subtype PGE2 receptor EP1 subtype prostaglandin E receptor 1 (subtype EP1), 42kDa prostanoid EP1 receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	405
Amino acid sequence	MSPYGLNLSLVDEATTCVTPRVPNTSVVLPTGGNGTSPALPIFSMTLGAVSNVLALALLAQVAGRLRRRRSTATFLLFVASLLAIDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTQPLIHAARVSVARARLALALLAAMALAVALLPLVHVGHYELQYPGTWCFISLGPPGGWRQALLAGLFAGLGLAALLAALVCNTLSGLALLRARWRRRRSRRFRENAGPDDRRRWGSRGLRLASASSASSITSTTAALRSSRGGGSARRVHAHDVEMVGQLVGIMVVSCICWSPLLVLVVLAIGGWNSNSLQRPLFLAVRLASWNQILDPWVYILLRQAMLRQLLRLLPLRVSAKGGPTELSLTKSAWEASSLRSSRHSGFSHL
UniProt	P70597
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5068
IUPHAR	340
DrugBank	N/A

Ligand

Name	SCHEMBL6117454
Molecular formula	C19H14ClNO5
IUPAC name	5-[[6-chloro-2-(furan-3-yl)-5-methoxyindol-1-yl]methyl]furan-2-carboxylic acid
Molecular weight	371.773
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	3.9
Synonyms	US8680120, 25-38 CHEMBL3665573 BDBM119479
Inchi Key	NPLRLZMOUSTGKG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H14ClNO5/c1-24-18-7-12-6-15(11-4-5-25-10-11)21(16(12)8-14(18)20)9-13-2-3-17(26-13)19(22)23/h2-8,10H,9H2,1H3,(H,22,23)
PubChem CID	50908090
ChEMBL	CHEMBL3665573
IUPHAR	N/A
BindingDB	119479
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	22.0 nM	, None	BindingDB,ChEMBL

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