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GPCR

NameGastric inhibitory polypeptide receptor
SpeciesHomo sapiens (Human)
GeneGIPR
SynonymGIP-R
GIP receptor
Glucose-dependent insulinotropic polypeptide receptor
Gippr
DiseaseType 2 diabetes
Length466
Amino acid sequenceMTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPPSGLACNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQWGLWRDHTQCENPEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHINLFTSFMLRAAAILSRDRLLPRPGPYLGDQALALWNQALAACRTAQIVTQYCVGANYTWLLVEGVYLHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKAIWWIIRTPILMTILINFLIFIRILGILLSKLRTRQMRCRDYRLRLARSTLTLVPLLGVHEVVFAPVTEEQARGALRFAKLGFEIFLSSFQGFLVSVLYCFINKEVQSEIRRGWHHCRLRRSLGEEQRQLPERAFRALPSGSGPGEVPTSRGLSSGTLPGPGNEASRELESYC
UniProtP48546
Protein Data BankN/A
GPCR-HGmod modelP48546
3D structure modelThis predicted structure model is from GPCR-EXP P48546.
BioLiPN/A
Therapeutic Target DatabaseT41750
ChEMBLCHEMBL4383
IUPHAR248
DrugBankN/A

Ligand

NameCHEMBL2159350
Molecular formulaC33H30ClN3O5
IUPAC name3-[[4-[(1S)-1-[3-(3-chloro-5-methoxyphenyl)-5-(6-methoxynaphthalen-2-yl)pyrazol-1-yl]ethyl]benzoyl]amino]propanoic acid
Molecular weight584.069
Hydrogen bond acceptor6
Hydrogen bond donor2
XlogP6.1
SynonymsBDBM50393777
Inchi KeyNQTQKODPPXEPJV-FQEVSTJZSA-N
Inchi IDInChI=1S/C33H30ClN3O5/c1-20(21-4-6-22(7-5-21)33(40)35-13-12-32(38)39)37-31(19-30(36-37)26-15-27(34)18-29(17-26)42-3)25-9-8-24-16-28(41-2)11-10-23(24)14-25/h4-11,14-20H,12-13H2,1-3H3,(H,35,40)(H,38,39)/t20-/m0/s1
PubChem CID60171060
ChEMBLCHEMBL2159350
IUPHARN/A
BindingDB50393777
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC504996.0 nMPMID22708876BindingDB,ChEMBL

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