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GPCR

NameGlucagon receptor
SpeciesRattus norvegicus (Rat)
GeneGcgr
SynonymGGR
GL-R
glucagon receptor
GR
DiseaseN/A for non-human GPCRs
Length485
Amino acid sequenceMLLTQLHCPYLLLLLVVLSCLPKAPSAQVMDFLFEKWKLYSDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPPNTTANISCPWYLPWYHKVQHRLVFKRCGPDGQWVRGPRGQSWRDASQCQMDDDEIEVQKGVAKMYSSYQVMYTVGYSLSLGALLLALVILLGLRKLHCTRNYIHGNLFASFVLKAGSVLVIDWLLKTRYSQKIGDDLSVSVWLSDGAVAGCRVATVIMQYGIIANYCWLLVEGVYLYSLLSITTFSEKSFFSLYLCIGWGSPLLFVIPWVVVKCLFENVQCWTSNDNMGFWWILRIPVLLAILINFFIFVRIIHLLVAKLRAHQMHYADYKFRLARSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSTKLFFDLFFSSFQGLLVAVLYCFLNKEVQAELLRRWRRWQEGKALQEERMASSHGSHMAPAGTCHGDPCEKLQLMSAGSSSGTGCEPSAKTSLASSLPRLADSPT
UniProtP30082
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4720
IUPHAR251
DrugBankN/A

Ligand

NameCHEMBL411904
Molecular formulaC86H127N25O30
IUPAC name(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3R)-2-[[2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-amino-3-(1H-imidazol-4-yl)propanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]acetyl]amino]-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-3-hydroxypropanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid
Molecular weight1991.11
Hydrogen bond acceptor34
Hydrogen bond donor33
XlogP-15.0
SynonymsN/A
Inchi KeyNRPKBIMSAIMHTA-FIQDZKBESA-N
Inchi IDInChI=1S/C86H127N25O30/c1-41(2)27-54(73(128)103-58(32-65(90)121)76(131)108-62(38-114)81(136)99-53(85(140)141)14-10-26-94-86(91)92)100-74(129)55(29-45-15-19-48(118)20-16-45)101-72(127)51(13-8-9-25-87)97-80(135)61(37-113)107-75(130)56(30-46-17-21-49(119)22-18-46)102-77(132)59(33-67(123)124)104-82(137)63(39-115)109-84(139)69(43(4)117)111-78(133)57(28-44-11-6-5-7-12-44)105-83(138)68(42(3)116)110-66(122)35-95-71(126)52(23-24-64(89)120)98-79(134)60(36-112)106-70(125)50(88)31-47-34-93-40-96-47/h5-7,11-12,15-22,34,40-43,50-63,68-69,112-119H,8-10,13-14,23-33,35-39,87-88H2,1-4H3,(H2,89,120)(H2,90,121)(H,93,96)(H,95,126)(H,97,135)(H,98,134)(H,99,136)(H,100,129)(H,101,127)(H,102,132)(H,103,128)(H,104,137)(H,105,138)(H,106,125)(H,107,130)(H,108,131)(H,109,139)(H,110,122)(H,111,133)(H,123,124)(H,140,141)(H4,91,92,94)/t42-,43-,50+,51+,52+,53+,54+,55+,56+,57+,58+,59+,60+,61+,62+,63+,68+,69+/m1/s1
PubChem CID44277637
ChEMBLCHEMBL411904
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Relative binding0.0001 %PMID11311060ChEMBL

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