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GPCR

NameMuscarinic acetylcholine receptor M1
SpeciesMus musculus (Mouse)
GeneChrm1
Synonymcholinergic receptor, muscarinic 1
cholinergic receptor, muscarinic 1, CNS
cholinergic receptor
M1 muscarinic acetylcholine receptor
M1 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length460
Amino acid sequenceMNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
UniProtP12657
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3733
IUPHAR13
DrugBankN/A

Ligand

NameCHEMBL1178328
Molecular formulaC11H14N4O
IUPAC name3-pent-1-ynyl-5-(1,4,5,6-tetrahydropyrimidin-5-yl)-1,2,4-oxadiazole
Molecular weight218.26
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP1.0
SynonymsBDBM50057403
5-(3-Pent-1-ynyl-[1,2,4]oxadiazol-5-yl)-1,4,5,6-tetrahydro-pyrimidine; TFA
Inchi KeyNSTHAUORMQSLDV-UHFFFAOYSA-N
Inchi IDInChI=1S/C11H14N4O/c1-2-3-4-5-10-14-11(16-15-10)9-6-12-8-13-7-9/h8-9H,2-3,6-7H2,1H3,(H,12,13)
PubChem CID10822690
ChEMBLN/A
IUPHARN/A
BindingDB50057403
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki17.0 nMPMID9111297BindingDB
Ki138.0 nMPMID9111297BindingDB

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