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GPCR

NameHistamine H4 receptor
SpeciesRattus norvegicus (Rat)
GeneHrh4
SynonymGPCR105
H4 receptor
H4R
HH4R
DiseaseN/A for non-human GPCRs
Length391
Amino acid sequenceMSESNGTDVLPLTAQVPLAFLMSLLAFAITIGNAVVILAFVADRNLRHRSNYFFLNLAISDFFVGVISIPLYIPHTLFNWNFGSGICMFWLITDYLLCTASVYSIVLISYDRYQSVSNAVRYRAQHTGILKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTEECEPGFVTEWYILAITAFLEFLLPVSLVVYFSVQIYWSLWKRGSLSRCPSHAGFIATSSRGTGHSRRTGLACRTSLPGLKEPAASLHSESPRGKSSLLVSLRTHMSGSIIAFKVGSFCRSESPVLHQREHVELLRGRKLARSLAVLLSAFAICWAPYCLFTIVLSTYRRGERPKSIWYSIAFWLQWFNSLINPFLYPLCHRRFQKAFWKILCVTKQPAPSQTQSVSS
UniProtQ91ZY1
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4468
IUPHAR265
DrugBankN/A

Ligand

Namehistamine
Molecular formulaC5H9N3
IUPAC name2-(1H-imidazol-5-yl)ethanamine
Molecular weight111.148
Hydrogen bond acceptor2
Hydrogen bond donor2
XlogP-0.7
SynonymsTox21_110166_1
Istamina
[3H]histamine
KBio2_003025
KBioGR_001580
[ Show all ]
Inchi KeyNTYJJOPFIAHURM-UHFFFAOYSA-N
Inchi IDInChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
PubChem CID774
ChEMBLCHEMBL90
IUPHAR1247, 1204
BindingDB7966, 50121205
DrugBankDB05381

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50158.49 nMPMID21044842ChEMBL
Intrinsic activity1.0 -PMID21044842ChEMBL
Kd125.893 nMPMID11561071IUPHAR
Ki63.0957 nMPMID11561071IUPHAR
Ki63.1 nMPMID21044842ChEMBL
Ki136.0 nMPMID25993395BindingDB,ChEMBL

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