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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	N-formyl peptide receptor 2
Species	Homo sapiens (Human)
Gene	FPR2
Synonym	FPRH1 FPRH2 FPRL1 HM63 Lipoxin A4 receptor LXA4 receptor LXA4R FPR2A FPR2/ALX Fpr-rs2 ALX ALX/FPR2 ALXR FMLP-R-I FMLP-related receptor I FMLPX formyl peptide receptor 2 formyl peptide receptor, related sequence 2 Formyl peptide receptor-like 1 RFP [ Show all ]
Disease	N/A
Length	351
Amino acid sequence	METNFSTPLNEYEEVSYESAGYTVLRILPLVVLGVTFVLGVLGNGLVIWVAGFRMTRTVTTICYLNLALADFSFTATLPFLIVSMAMGEKWPFGWFLCKLIHIVVDINLFGSVFLIGFIALDRCICVLHPVWAQNHRTVSLAMKVIVGPWILALVLTLPVFLFLTTVTIPNGDTYCTFNFASWGGTPEERLKVAITMLTARGIIRFVIGFSLPMSIVAICYGLIAAKIHKKGMIKSSRPLRVLTAVVASFFICWFPFQLVALLGTVWLKEMLFYGKYKIIDILVNPTSSLAFFNSCLNPMLYVFVGQDFRERLIHSLPTSLERALSEDSAPTNDTAANSASPPAETELQAM
UniProt	P25090
Protein Data Bank	N/A
GPCR-HGmod model	P25090
3D structure model	This predicted structure model is from GPCR-EXP P25090.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4227
IUPHAR	223
DrugBank	N/A

Ligand

Name	Amedin
Molecular formula	C18H27NO3
IUPAC name	2-(dimethylamino)ethyl 2-cyclohexyl-2-hydroxy-2-phenylacetate
Molecular weight	305.418
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.4
Synonyms	2-dimethylaminoethyl 2-cyclohexyl-2-hydroxy-2-phenylacetate AKOS022081914 Dimethylamainoethyl 2-cyclohexyl-2-hydroxy-2-phenyl acetate STK067602 2-(dimethylamino)ethyl 2-cyclohexyl-2-hydroxy-2-phenylacetate;hydrochloride 6834-29-3 (hydrochloride) BDBM37618 MLS000068648 2-cyclohexyl-2-hydroxy-2-phenyl-acetic acid 2-(dimethylamino)ethyl ester;hydrochloride AC1Q67OL CTK5C7828 NCGC00072871-03 25520-98-3 Dimethylaminoethylphenylcyclohexyl glycolic acid 2-(dimethylamino)ethyl 2-cyclohexyl-2-oxidanyl-2-phenyl-ethanoate;hydrochloride AB00479718-09 CHEMBL1619633 MolPort-001-910-147 2-cyclohexyl-2-hydroxy-2-phenylacetic acid 2-(dimethylamino)ethyl ester;hydrochloride AKOS003658236 Cyclohexyl-hydroxy-phenyl-acetic acid 2-dimethylamino-ethyl ester SMR000012218 BAS 03334766 MCULE-7935218798 2-(dimethylamino)ethyl cyclohexyl(hydroxy)phenylacetate AC1L51RD cid_3083979 NCGC00072871-02 [ Show all ]
Inchi Key	BGUILKOLBPOILU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H27NO3/c1-19(2)13-14-22-17(20)18(21,15-9-5-3-6-10-15)16-11-7-4-8-12-16/h3,5-6,9-10,16,21H,4,7-8,11-14H2,1-2H3
PubChem CID	168386
ChEMBL	N/A
IUPHAR	N/A
BindingDB	37618
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<66700.0 nM	N/A	BindingDB
Ki	<40300.0 nM	N/A	BindingDB

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