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GPCR

NameFree fatty acid receptor 1
SpeciesHomo sapiens (Human)
GeneFFAR1
SynonymFFA1R
G protein-coupled receptor 40
G-protein coupled receptor 40
GPR40
FFA1 receptor
DiseaseType 2 diabetes
Non-insulin dependent diabetes
Diabetes
Length300
Amino acid sequenceMDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
UniProtO14842
Protein Data Bank5tzy, 5tzr
GPCR-HGmod modelO14842
3D structure modelThis structure is from PDB ID 5tzy.
BioLiPBL0380462, BL0380463, BL0380464
Therapeutic Target DatabaseT25608
ChEMBLCHEMBL4422
IUPHAR225
DrugBankBE0000688

Ligand

NameCHEMBL2315249
Molecular formulaC18H16O3
IUPAC name3-[4-[2-[2-(hydroxymethyl)phenyl]ethynyl]phenyl]propanoic acid
Molecular weight280.323
Hydrogen bond acceptor3
Hydrogen bond donor2
XlogP2.8
SynonymsSCHEMBL12087493
Inchi KeyBGYHRAMMUCXREZ-UHFFFAOYSA-N
Inchi IDInChI=1S/C18H16O3/c19-13-17-4-2-1-3-16(17)11-9-14-5-7-15(8-6-14)10-12-18(20)21/h1-8,19H,10,12-13H2,(H,20,21)
PubChem CID58319142
ChEMBLCHEMBL2315249
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Activity111.0 %PMID23294321ChEMBL
EC50575.44 nMPMID23294321ChEMBL

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