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GLASS

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GPCR

Name	5-hydroxytryptamine receptor 2A
Species	Homo sapiens (Human)
Gene	HTR2A
Synonym	5-HT-2 serotonin receptor 2A serotonin 5HT-2 receptor 5-HT-2A 5-HT2A receptor 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 5Ht-2 'D' receptor [ Show all ]
Disease	Depression Unspecified Diabetes Erythropoietic porphyria Fibromyalgia Sleep disorders Schizophrenia Psychiatric disorder Pancreatitis Mood disorder Migraine Hemorrhoids Glaucoma Central nervous system disease Cardiovascular disorder Addiction Schizophrenia; Sleep maintenance insomnia Alcohol use disorders Anxiety disorder [ Show all ]
Length	471
Amino acid sequence	MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
UniProt	P28223
Protein Data Bank	6a93, 6a94
GPCR-HGmod model	P28223
3D structure model	This structure is from PDB ID 6a93.
BioLiP	BL0441025,BL0441028, BL0441031, BL0441030,BL0441033, BL0441029,BL0441032, BL0441026, BL0441024,BL0441027
Therapeutic Target Database	T32060
ChEMBL	CHEMBL224
IUPHAR	6
DrugBank	BE0000451

Ligand

Name	Phenethylamine
Molecular formula	C8H11N
IUPAC name	2-phenylethanamine
Molecular weight	121.183
Hydrogen bond acceptor	1
Hydrogen bond donor	1
XlogP	1.4
Synonyms	EINECS 200-574-4 HMS2267J14 71750-39-5 (sulfate) LABOTEST-BB LT03331710 843-EP2281818A1 843-EP2371811A2 (2-phenylethyl)amine AKOS000119084 .beta.-Phenylethylamine hydrochloride b-phenylaethylamin 12463-EP2280001A1 beta-Phenethylamine 2-(aminoethyl)benzene BRN 0507488 2-penylethylamine D0Q6PI 2-Phenylethanamine # MLS001066395 NSC10811 phenethylamin phenethylarnine RL04441 ST24032521 2-phenylethaneamine F2190-0396 3-AMINOETHYLBENZENE I01-0392 79541-EP2305697A2 LS10634 843-EP2292619A1 (+)-alpha-Methylphenethylamine hemisulfate salt AC1Q54D9 .beta.-Phenethylamine AS00484 1-Phenyl-2-amino-athan BDBM10758 14C-phenylethylamine beta-Phenylaethylamin [German] 2-Amino-fenylethan CHEBI:18397 2-Phenethylamine, liquid Dextroamphetamine sulfate salt N-Benzylmethyl-amine P0085 Phenethylamine, 99% Polystyrene A-NH2 SBB058801 TR-000856 EBD27214 2-phenylethylamine FT-0613300 60BC7032-7CEC-4B97-B365-EA6E475E6E3C KS-000002OD 843-EP2272973A1 843-EP2308510A1 (2-Aminoethyl)benzene AI3-03117 .beta.-Phenylathylaminhydrochlorid b-aminoethylbenzene 1-Phenyl-2-aminoethane beta Phenethylamine 1utm bmse000377 2-Fenylethylamin CS-W011199 2-Phenylethan-1-Amine NSC 10811 phenethyl amine PHENETHYLAMINE, HYDROCHLORIDE Q-201553 SCHEMBL968 WLN: Z2R Ethanamine, 2-phenyl- 21691-EP2284174A1 HSDB 3526 79541-EP2305695A2 LABOTEST-BB LTBB000487 843-EP2284157A1 AC1L1AIE AN-23735 .omega.-Phenylethylamine b-phenylaethylamin (german) 12463-EP2314571A2 beta-Phenylaethylamin 2-(phenyl)ethylamine C05332 2-Phenethylamine DB-002852 2-phenylethanamine (ACD/Name 4.0) MLS001075768 omega-Phenylethylamine Phenylethyl amine RP19436 ST45255355 2-phenylethariamine FEMA 3220 327C7L2BXQ InChI=1/C8H11N/c9-7-6-8-4-2-1-3-5-8/h1-5H,6-7,9H 79541-EP2305698A2 MCULE-5305816256 843-EP2295439A1 (+)-alpha-Methylphenethylamine sulfate salt ACMC-1ATT1 .beta.-Phenethylamine hydrochloride AURORA KA-7805 1-Phenyl-2-amino-athan (GERMAN) Benzeneethanamine 156-28-5 (hydrochloride) beta-phenylethylamine 2-Amino-fenylethan [Czech] 2-phenyl-Ethanamine DL-BENZEDRINE SULFATE N-phenethylamine PARAGOS 510015 Phenethylamine, >=99% Polystyrene A-NH2, extent of labeling: 0.8-1.2 mmol/g loading SC-18356 TX-016680 EC 200-574-4 2-phenylethylamine (ACD/Name 4.0) GTPL2144 64-04-0 KSC353A6F 843-EP2277872A1 843-EP2308562A2 (2-Aminoethyl)polystyrene AJ-61320 .beta.-Phenylethylamine b-phenethylamine beta-Aminoethylbenzene 1uto BR-44044 2-Fenylethylamin [Czech] CTK2F3062 2-Phenylethanamine MFCD00008184 NSC-10811 phenethyl-amine Phenethylamine, purified by redistillation, >=99.5% RARECHEM AL BW 0047 SMR000471837 ZINC6579654 Ethylamine, 2-phenyl- 21691-EP2314571A2 HY-W010483 79541-EP2305696A2 LS-3025 843-EP2284174A1 (+)-A-METHYLPHENETHYLAMINE HEMISULFATE SALT AC1Q54BB .beta.-Aminoethylbenzene ANW-34793 1-Amino-2-phenylethane b-phenylethylamine 12463-EP2316826A1 beta-phenylaethylamin (german) 2-Amino-1-phenylethane C8H11N 2-Phenethylamine, analytical standard DB04325 2-phenylethanaminium MolPort-000-871-498 OTAVA-BB 1038619 Phenethylamine, .beta. phenylethylamine RTR-000856 STL264196 2-Phenylethyl amine FEMA No. 3220 5471-08-9 (sulfate[2:1]) KB-47544 843-EP2272972A1 843-EP2305260A1 (+/-)-ALPHA-METHYLPHENETHYLAMINE SULFATE SALT ACT01135 .beta.-Phenylaethylamin AZ0001-0092 1-Phenyl-2-amino-athan [German] benzylmethyl amine 1tnj BHHGXPLMPWCGHP-UHFFFAOYSA-N 2-Aminoethylbenzene CHEMBL610 2-phenyl-ethylamine DTXSID5058773 NCGC00163366-01 PHEA PHENETHYLAMINE, BETA PubChem21080 SCHEMBL330324 UNII-327C7L2BXQ [ Show all ]
Inchi Key	BHHGXPLMPWCGHP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C8H11N/c9-7-6-8-4-2-1-3-5-8/h1-5H,6-7,9H2
PubChem CID	1001
ChEMBL	CHEMBL610
IUPHAR	2144
BindingDB	10758
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID14660041	PDSP,BindingDB
Ki	16800.0 nM	PMID18847250, PMID11931619	BindingDB,ChEMBL

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