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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Prostaglandin D2 receptor
Species	Homo sapiens (Human)
Gene	PTGDR
Synonym	PGD2 receptor DP1 DP1 receptor PTGDR1 prostanoid DP receptor-like Prostanoid DP receptor prostaglandin D2 receptor (DP) PGD receptor [ Show all ]
Disease	Pain Dyslipidaemias Rhinitis Thromboembolism Thrombosis Atopic dermatitis Asthma Allergy Allergic rhinitis [ Show all ]
Length	359
Amino acid sequence	MKSPFYRCQNTTSVEKGNSAVMGGVLFSTGLLGNLLALGLLARSGLGWCSRRPLRPLPSVFYMLVCGLTVTDLLGKCLLSPVVLAAYAQNRSLRVLAPALDNSLCQAFAFFMSFFGLSSTLQLLAMALECWLSLGHPFFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKFVQYCPGTWCFIQMVHEEGSLSVLGYSVLYSSLMALLVLATVLCNLGAMRNLYAMHRRLQRHPRSCTRDCAEPRADGREASPQPLEELDHLLLLALMTVLFTMCSLPVIYRAYYGAFKDVKEKNRTSEEAEDLRALRFLSVISIVDPWIFIIFRSPVFRIFFHKIFIRPLRYRSRCSNSTNMESSL
UniProt	Q13258
Protein Data Bank	N/A
GPCR-HGmod model	Q13258
3D structure model	This predicted structure model is from GPCR-EXP Q13258.
BioLiP	N/A
Therapeutic Target Database	T68782
ChEMBL	CHEMBL4427
IUPHAR	338
DrugBank	BE0000296

Ligand

Name	CHEMBL364593
Molecular formula	C27H23NO6
IUPAC name	2-[1-[4-[[(3R)-2,3-dihydro-1,4-benzodioxin-3-yl]methoxy]benzoyl]-2-methylindol-4-yl]acetic acid
Molecular weight	457.482
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	4.9
Synonyms	{1-[4-(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethoxy)-benzoyl]-2-methyl-1H-indol-4-yl}-acetic acid BDBM50152508 SCHEMBL990585
Inchi Key	OCCPUDPMKJXBQC-OAQYLSRUSA-N
Inchi ID	InChI=1S/C27H23NO6/c1-17-13-22-19(14-26(29)30)5-4-6-23(22)28(17)27(31)18-9-11-20(12-10-18)32-15-21-16-33-24-7-2-3-8-25(24)34-21/h2-13,21H,14-16H2,1H3,(H,29,30)/t21-/m1/s1
PubChem CID	44394380
ChEMBL	CHEMBL364593
IUPHAR	N/A
BindingDB	50152508
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	30.0 nM	PMID15341946	BindingDB,ChEMBL
Ki	10.0 nM	PMID15341946	BindingDB,ChEMBL

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