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GPCR

NameNeuropeptide Y receptor type 2
SpeciesHomo sapiens (Human)
GeneNPY2R
SynonymNPY2-R
NPY-Y2 receptor
neuropeptide Y receptor type 2
Y2 receptor
DiseaseDiabetes
Metabolic disorders
Obesity
Length381
Amino acid sequenceMGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYTRIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAKKNLEVRKNSGPNDSFTEATNV
UniProtP49146
Protein Data BankN/A
GPCR-HGmod modelP49146
3D structure modelThis predicted structure model is from GPCR-EXP P49146.
BioLiPN/A
Therapeutic Target DatabaseT10670
ChEMBLCHEMBL4018
IUPHAR306
DrugBankBE0002419

Ligand

NameCHEMBL549895
Molecular formulaC23H25ClF3N3O2
IUPAC nameN-[3-chloro-4-[4-[3-(trifluoromethyl)benzoyl]piperazin-1-yl]phenyl]-2,2-dimethylpropanamide
Molecular weight467.917
Hydrogen bond acceptor6
Hydrogen bond donor1
XlogP5.1
SynonymsBDBM50414450
Inchi KeyBHHRBLRONYLABD-UHFFFAOYSA-N
Inchi IDInChI=1S/C23H25ClF3N3O2/c1-22(2,3)21(32)28-17-7-8-19(18(24)14-17)29-9-11-30(12-10-29)20(31)15-5-4-6-16(13-15)23(25,26)27/h4-8,13-14H,9-12H2,1-3H3,(H,28,32)
PubChem CID45271522
ChEMBLCHEMBL549895
IUPHARN/A
BindingDB50414450
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Ki125.89 nMPMID19581086BindingDB,ChEMBL

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