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Name | Thromboxane A2 receptor |
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Species | Homo sapiens (Human) |
Gene | TBXA2R |
Synonym | TP receptor TXA2-R prostanoid TP receptor |
Disease | Diabetic neuropathy Cardiovascular disorder Erectile dysfunction Perennial allergic rhinitis Peripheral vascular disease [ Show all ] |
Length | 343 |
Amino acid sequence | MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTRSSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPGSWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWNQILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ |
UniProt | P21731 |
Protein Data Bank | 6iiv, 6iiu |
GPCR-HGmod model | P21731 |
3D structure model | This structure is from PDB ID 6iiv. |
BioLiP | BL0436518, BL0436517, BL0436516, BL0436515, BL0436514, BL0436513 |
Therapeutic Target Database | T76198 |
ChEMBL | CHEMBL2069 |
IUPHAR | 346 |
DrugBank | BE0000759 |
Name | TMQ, 5-TrifluoroMe |
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Molecular formula | C20H22F3NO5 |
IUPAC name | 5-(trifluoromethyl)-1-[(3,4,5-trimethoxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol |
Molecular weight | 413.393 |
Hydrogen bond acceptor | 9 |
Hydrogen bond donor | 3 |
XlogP | 3.4 |
Synonyms | CHEMBL143645 BDBM82504 PDSP1_000601 PDSP2_000598 |
Inchi Key | BHLICJAYUSKMQT-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C20H22F3NO5/c1-27-15-7-10(8-16(28-2)19(15)29-3)6-13-12-9-14(25)18(26)17(20(21,22)23)11(12)4-5-24-13/h7-9,13,24-26H,4-6H2,1-3H3 |
PubChem CID | 15133335 |
ChEMBL | CHEMBL143645 |
IUPHAR | N/A |
BindingDB | 82504 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 831764.0 nM | PMID1346651 | BindingDB |
IC50 | 1.20226e+12 nM | PMID1346651 | ChEMBL |
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