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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 2A
Species	Sus scrofa (Pig)
Gene	HTR2A
Synonym	5-HT-2 5-HT-2A 5-HT2A Serotonin receptor 2A
Disease	N/A for non-human GPCRs
Length	470
Amino acid sequence	MDVLCEENTSLSSPTNSFMQLNDDTRLYHNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPPCFSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHRRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQTGQKENSKQDDKATENDCTMVALGKQHSEDAPADNSNTVNEKVSCV
UniProt	P50129
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2490
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL1923292
Molecular formula	C19H21FN2O2
IUPAC name	1-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-[(4-fluorophenyl)methyl]piperazine
Molecular weight	328.387
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	3.2
Synonyms	1-(1,4 benzodioxan-6-yl)-4-(4-fluorobenzyl) piperazine BDBM50358838 OEFFTIMBYVFOPK-UHFFFAOYSA-N 1-(1,4 benzodioxan-6-yl)-4-(4-fluorobenzyl)piperazine SCHEMBL7527827
Inchi Key	OEFFTIMBYVFOPK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H21FN2O2/c20-16-3-1-15(2-4-16)14-21-7-9-22(10-8-21)17-5-6-18-19(13-17)24-12-11-23-18/h1-6,13H,7-12,14H2
PubChem CID	9797495
ChEMBL	CHEMBL1923292
IUPHAR	N/A
BindingDB	50358838
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	7000.0 nM	PMID22039961	BindingDB,ChEMBL

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