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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Alpha-2A adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRA2A
Synonym	alpha2D alpha2A-AR alpha2A-adrenoceptor alpha2A-adrenergic receptor alpha2A Alpha-2AAR Adra-2 Adra-2a ADRA2 ADRA2R Adrenergic alpha 2A receptor adrenergic receptor Alpha-2 adrenergic receptor subtype C10 Alpha-2A adrenoceptor Alpha-2A adrenoreceptor [ Show all ]
Disease	Attention deficit hyperactivity disorder Sexual dysfunction Pain
Length	450
Amino acid sequence	MGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAVAAPPGGTERRPNGLGPERSAGPGGAEAEPLPTQLNGAPGEPAPAGPRDTDALDLEESSSSDHAERPPGPRRPERGPRGKGKARASQVKPGDSLPRRGPGATGIGTPAAGPGEERVGAAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
UniProt	P08913
Protein Data Bank	N/A
GPCR-HGmod model	P08913
3D structure model	This predicted structure model is from GPCR-EXP P08913.
BioLiP	N/A
Therapeutic Target Database	T11448
ChEMBL	CHEMBL1867
IUPHAR	25
DrugBank	BE0000289

Ligand

Name	Phentolamine mesylate
Molecular formula	C18H23N3O4S
IUPAC name	3-[N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-4-methylanilino]phenol;methanesulfonic acid
Molecular weight	377.459
Hydrogen bond acceptor	6
Hydrogen bond donor	3
XlogP	None
Synonyms	Lopac-P-7561 MolPort-003-959-154 P 7561 Phentolamine mesilate [INN:BAN] 2-[N-(m-Hydroxyphenyl)-p-toluidinomethyl]imidazoline, methanesulfonate Phentolamine mesylate, United States Pharmacopeia (USP) Reference Standard 3-[[(4,5-Dihydro-1H-imidazol-2- yl)methyl](4-methylphenyl)-amino]phenol mesylate Regitine (TN) AB0014005 SR-01000000055-3 BCP09845 W-104799 CS-2419 HMS3263E05 m-(N-(2-Imidazolin-2-ylmethyl)-p-toluidino)phenol monomethanesulfonate (salt) NCGC00094282-01 Phenol, m-(N-(2-imidazolin-2-ylmethyl)-p-toluidino)-, monomethanesulfonate (salt) Phentolamine Meslate,(S) 3-[4,5-dihydro-1H-imidazol-2-ylmethyl-(4-methylphenyl)amino]phenol; methanesulfonic acid Phentolamine methanesulfonate salt, >=98% (TLC), powder 4CA-1013 s2038 AC1L3M27 Tox21_500982 CCG-222286 DTXSID60215315 HY-B0362A K062 MLS000069487 Opera_ID_1599 Phentolamine mesilate (JAN/INN) 134P201 Phentolamine mesylate [USP] 3-[N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-4-methylanilino]phenol; methanesulfonic acid Regitin mesylate A828197 SMR000059054 AS-13800 Vasomax CHEMBL1200873 FT-0603267 LP00982 NCGC00016195-01 P1985 Phentolamine mesilate, British Pharmacopoeia (BP) Reference Standard 3-(((4,5-dihydro-1H-imidazol-2-yl)methyl)(p-tolyl)amino)phenol methanesulfonate Phentolamine methanesulfonate 3-[[(4,5-Dihydro-1H-imidazol-2-yl)methyl](4-methylphenyl)-amino]phenol mesylate Regitine mesylate AB2000443 ST057364 C17H19N3O.CH4O3S Y7543E5K9T CTK8G2357 HMS3373D03 I14-0396 MCULE-3770473461 NCGC00261667-01 Phentolamine (mesylate) 3-[N-(2-Imidazolin-2-ylmethyl)-p-toluidino]phenol methanesulphonate Phentolamine methanesulphonate 50-60-2 (Parent) SAM002703130 AKOS007930193 UNII-Y7543E5K9T CCRIS 9022 EINECS 200-604-6 KS-00000XQY MLS001076484 OraVerse Phentolamine mesilate for system suitability, European Pharmacopoeia (EP) Reference Standard 2-[N-(m-Hydroxyphenyl)-p-toluidinomethyl]imidazoline Methanesulfonate Phentolamine Mesylate, Pharmaceutical Secondary Standard; Certified Reference Material 3-[N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-4-methylanilino]phenol;methanesulfonic acid Regitin methanesulphonate A835046 SR-01000000055 BC200362 VZ33629 CPD000059054 HMS2233A24 LS-104726 NCGC00016195-02 Phenol, 3-(((4,5-dihydro-1H-imidazol-2-yl)methyl)(4-methylphenyl)amino)-, monomethanesulfonate (salt) Phentolamine mesilate, European Pharmacopoeia (EP) Reference Standard 3-[(2-imidazolin-2-ylmethyl)(4-methylphenyl)amino]phenol, methanesulfonic acid Phentolamine methanesulfonate salt 3-[[(4,5-Dihydro-1H-imidazol-2-yl)methyl](4-methylphenyl)amino]phenol methanesulfonate Regitine methanesulfonate AC-7472 SW196637-3 C18H23N3O4S Z-Max D00509 HMS3655B13 J10339 MFCD00134201 NV-101 phentolamine mesilate Phentolamine mesylate (USP) 3-[N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-4-methyl-anilino]phenol; methanesulfonic acid REGID_for_CID_91430 65-28-1 SCHEMBL40852 AN-8957 Vasofem EU-0100982 [ Show all ]
Inchi Key	OGIYDFVHFQEFKQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H19N3O.CH4O3S/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15;1-5(2,3)4/h2-8,11,21H,9-10,12H2,1H3,(H,18,19);1H3,(H,2,3,4)
PubChem CID	91430
ChEMBL	CHEMBL1200873
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
Ki	1.58 nM	PMID10611634	PDSP
Ki	2.6 nM	PMID11408545	PDSP
Ki	4.1 nM	PMID1353247	PDSP
Ki	19.95 nM	PMID10611634	PDSP
Ki	20.4174 nM	PMID9605427	PDSP

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