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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 4
Species	Cavia porcellus (Guinea pig)
Gene	HTR4
Synonym	5-HT-4 5-HT4 Serotonin receptor 4
Disease	N/A for non-human GPCRs
Length	388
Amino acid sequence	MDKLDANVSSKEGFGSVEKVVLLTFLSAVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWVYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHARQIQVLQRAGAPAEGRPQPADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQLWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDTVECGGQWESQCHPAASSPLVAAQPIDT
UniProt	O70528
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5017
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL36120
Molecular formula	C20H27N3O
IUPAC name	5-[(1-ethylpiperidin-4-yl)methoxy]-1,2,3,4-tetrahydrobenzo[h][1,6]naphthyridine
Molecular weight	325.456
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	4.0
Synonyms	BDBM50122723 6-(1-Ethylpiperidine-4-ylmethoxy)-7,8,9,10-tetrahydro-10-azabenzo[c]quinoline 9-Ethyl-5-(piperidin-4-ylmethoxy)-1,2,3,4-tetrahydro-benzo[h][1,6]naphthyridine
Inchi Key	BHTZPLFMKHSPED-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H27N3O/c1-2-23-12-9-15(10-13-23)14-24-20-17-7-5-11-21-19(17)16-6-3-4-8-18(16)22-20/h3-4,6,8,15,21H,2,5,7,9-14H2,1H3
PubChem CID	9858485
ChEMBL	CHEMBL36120
IUPHAR	N/A
BindingDB	50122723
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	55.0 %	PMID12502367	ChEMBL
Inhibition	100.0 %	PMID12502367	ChEMBL
Ki	13.0 nM	PMID12502367	BindingDB
Ki	13.1 nM	PMID12502367	ChEMBL

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