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Name | 5-hydroxytryptamine receptor 2C |
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Species | Homo sapiens (Human) |
Gene | HTR2C |
Synonym | Serotonin receptor 2C serotonin 1c receptor 5-HT1C 5-HT2C 5-HT-2C [ Show all ] |
Disease | Pain Sleep initiation and maintenance disorders; Primary insomnia; Schizophrenia Unspecified Depression Drug abuse [ Show all ] |
Length | 458 |
Amino acid sequence | MVNLRNAVHSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV |
UniProt | P28335 |
Protein Data Bank | 6bqg, 6bqh |
GPCR-HGmod model | P28335 |
3D structure model | This structure is from PDB ID 6bqg. |
BioLiP | BL0404805, BL0404806 |
Therapeutic Target Database | T83813 |
ChEMBL | CHEMBL225 |
IUPHAR | 8 |
DrugBank | BE0004957, BE0004881, BE0000533 |
Name | 2-Methoxyethoxymethyl chloride |
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Molecular formula | C4H9ClO2 |
IUPAC name | 1-(chloromethoxy)-2-methoxyethane |
Molecular weight | 124.564 |
Hydrogen bond acceptor | 2 |
Hydrogen bond donor | 0 |
XlogP | 0.6 |
Synonyms | TR-015853 1-Chloromethoxy-2-methoxy-ethane 2-methoxyethoxy methylchloride 6643-EP1441224A2 AKOS000121064 [ Show all ] |
Inchi Key | BIAAQBNMRITRDV-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C4H9ClO2/c1-6-2-3-7-4-5/h2-4H2,1H3 |
PubChem CID | 77590 |
ChEMBL | N/A |
IUPHAR | N/A |
BindingDB | 85388 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 124.0 nM | PMID9933142 | BindingDB |
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