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GPCR

Name	5-hydroxytryptamine receptor 2B
Species	Homo sapiens (Human)
Gene	HTR2B
Synonym	stomach fundus serotonin receptor serotonin receptor 2B 5-HT2F 5-HT-2B 5-HT2B 5-HT2B receptor 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled [ Show all ]
Disease	Psychoses Migraine Irritable bowel syndrome Depression; Cerebral infarction Coronary heart disease Congestive heart failure Pulmonary arterial hypertension [ Show all ]
Length	481
Amino acid sequence	MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV
UniProt	P41595
Protein Data Bank	5tud, 5tvn, 6drx, 4ib4, 4nc3, 6dry, 6drz, 6ds0
GPCR-HGmod model	P41595
3D structure model	This structure is from PDB ID 5tud.
BioLiP	BL0425280, BL0425283, BL0425282, BL0239858, BL0239859, BL0265182, BL0265183, BL0368464, BL0425281, BL0385686,BL0385687, BL0425284, BL0425285, BL0425286, BL0368465, BL0425287
Therapeutic Target Database	T31204
ChEMBL	CHEMBL1833
IUPHAR	7
DrugBank	BE0000393

Ligand

Name	2-Methoxyethoxymethyl chloride
Molecular formula	C4H9ClO2
IUPAC name	1-(chloromethoxy)-2-methoxyethane
Molecular weight	124.564
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	0.6
Synonyms	2-methoxy-ethoxymethylchloride 2-methoxyethyl chloromethyl ether AC1L2TDS BETA-METHOXYETHOXYMETHYLCHLORIDE DTXSID8063250 J-509862 MEM chloride Methoxyethoxymethyl chloride SC-75748 1-(Chloromethoxy)-2-methoxyethane 2-methoxyethoxy methylchloride 6643-EP1441224A2 AKOS000121064 CAS_3970-21-6 Ethane,1-(chloromethoxy)-2-methoxy- KB-68943 MEM-chloride MFCD00000888 (2-methoxyethoxy)methyl chloride TR-015853 1-Chloromethoxy-2-methoxy-ethane 2-Methoxyethoxymethyl chloride, Technical grade 847026-64-6 BDBM85388 CTK3J1136 I14-0060 L001239 methoxy ethoxymethyl chloride RP19610 .beta.-Methoxyethoxymethyl chloride 2-methoxy ethoxymethyl chloride 2-methoxyethoxy chloromethane 2methoxyethoxymethyl chloride AC1Q3VDW BIAAQBNMRITRDV-UHFFFAOYSA- EINECS 223-589-8 Jsp006889 MEM chloride (2-Methoxyethoxymethyl chloride) methoxyethoxymethylchloride (2-methoxy-ethoxy)methyl chloride SCHEMBL329 1-(Chloromethoxy)-2-methoxyethane # 2-methoxyethoxy-methyl chloride 6643-EP2295412A1 Alkoxyethoxymethylchloride chloromethoxyethoxymethane Ethylene Glycol Chloromethyl Methyl Ether KS-000001EV MEM-Cl MolPort-001-768-805 (2-methoxyethoxy)methylchloride TRA0067120 1-Chloromethoxy-2-methoxyethane 2-methoxy-ethoxymethyl chloride 2-methoxyethoxymethylchloride beta-Methoxyethoxymethyl chloride DB-019132 InChI=1/C4H9ClO2/c1-6-2-3-7-4-5/h2-4H2,1H3 M0680 methoxyethoxychloromethane RTR-015853 1-(chloromethoxy)-2-methoxy-ethane 2-Methoxyethoxy methyl Chloride 3970-21-6 ACMC-1AGMY BIAAQBNMRITRDV-UHFFFAOYSA-N Ethane, 1-(chloromethoxy)-2-methoxy- K-8520 MEM chloride, 94% methoxyethyl chloromethyl ether (2-methoxyethoxy)-methyl chloride STR05536 1-Chloro-2,5-dioxahexane 6643-EP2295413A1 ANW-29145 chloromethyl 2-methoxyethyl ether FT-0612838 KSC491C3N MEMCl PubChem10093 (2-methyloxyethyl)oxymethylchlorid ZINC2242622 1-methoxy-2-chloromethoxyethane [ Show all ]
Inchi Key	BIAAQBNMRITRDV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C4H9ClO2/c1-6-2-3-7-4-5/h2-4H2,1H3
PubChem CID	77590
ChEMBL	N/A
IUPHAR	N/A
BindingDB	85388
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	763.0 nM	PMID9933142	BindingDB

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