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GPCR

NameHistamine H4 receptor
SpeciesRattus norvegicus (Rat)
GeneHrh4
SynonymH4 receptor
H4R
HH4R
GPCR105
DiseaseN/A for non-human GPCRs
Length391
Amino acid sequenceMSESNGTDVLPLTAQVPLAFLMSLLAFAITIGNAVVILAFVADRNLRHRSNYFFLNLAISDFFVGVISIPLYIPHTLFNWNFGSGICMFWLITDYLLCTASVYSIVLISYDRYQSVSNAVRYRAQHTGILKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTEECEPGFVTEWYILAITAFLEFLLPVSLVVYFSVQIYWSLWKRGSLSRCPSHAGFIATSSRGTGHSRRTGLACRTSLPGLKEPAASLHSESPRGKSSLLVSLRTHMSGSIIAFKVGSFCRSESPVLHQREHVELLRGRKLARSLAVLLSAFAICWAPYCLFTIVLSTYRRGERPKSIWYSIAFWLQWFNSLINPFLYPLCHRRFQKAFWKILCVTKQPAPSQTQSVSS
UniProtQ91ZY1
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4468
IUPHAR265
DrugBankN/A

Ligand

NameCHEMBL493664
Molecular formulaC14H18N6O
IUPAC name1-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]pyridin-2-one
Molecular weight286.339
Hydrogen bond acceptor6
Hydrogen bond donor1
XlogP0.5
SynonymsSCHEMBL2166681
Inchi KeyOJHQVXKWXRZSKG-UHFFFAOYSA-N
Inchi IDInChI=1S/C14H18N6O/c1-18-6-8-19(9-7-18)11-10-12(17-14(15)16-11)20-5-3-2-4-13(20)21/h2-5,10H,6-9H2,1H3,(H2,15,16,17)
PubChem CID25131561
ChEMBLCHEMBL493664
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC5014125.4 nMPMID18811133ChEMBL
Efficacy33.0 %PMID18811133ChEMBL

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