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GLASS

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GPCR

Name	Kappa-type opioid receptor
Species	Homo sapiens (Human)
Gene	OPRK1
Synonym	K-OR-1 KOPr OP2 KOP KOR-1 Kappa receptor [ Show all ]
Disease	Obesity Opiate dependence Inflammatory bowel disease Erythema Diarrhea-predominant IBS Unspecified Bipolar disorder Alcohol use disorders Pain Substance dependence Neurodegenerative disease [ Show all ]
Length	380
Amino acid sequence	MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
UniProt	P41145
Protein Data Bank	6b73, 4djh
GPCR-HGmod model	P41145
3D structure model	This structure is from PDB ID 6b73.
BioLiP	BL0402244,BL0402246, BL0224693,BL0224694, BL0402243,BL0402245
Therapeutic Target Database	T60693
ChEMBL	CHEMBL237
IUPHAR	318
DrugBank	BE0000632

Ligand

Name	(-)-Normorphine
Molecular formula	C16H17NO3
IUPAC name	1,2,3,4,4a,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol
Molecular weight	271.316
Hydrogen bond acceptor	4
Hydrogen bond donor	3
XlogP	0.3
Synonyms	BASE NORMORPHINE Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-, (5.alpha.,6.alpha.)- 4,5-Epoxy-3,6-dihydroxymorphin-7-ene Desmethylmorphine NSC-270042 Morphinan-3, 7,8-didehydro-4,5-epoxy-, (5.alpha.,6.alpha.)- SCHEMBL26388 BDBM85329 Morphinan-3,6.alpha.-diol, 7,8-didehydro-4,5.alpha.-epoxy- 4,6-dihydroxymorphin-7-ene FT-0673117 NSC270042 AC1L8OZM Morphinan-3, 7,8-didehydro-4,5.alpha.-epoxy- Demethylmorphine N-Normorphine 7,8-Didehydro-4,5alpha-epoxy-Morphinan-3,6alpha-diol L001224 ONBWJWYUHXVEJS-UHFFFAOYSA-N [ Show all ]
Inchi Key	ONBWJWYUHXVEJS-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H17NO3/c18-11-3-1-8-7-10-9-2-4-12(19)15-16(9,5-6-17-10)13(8)14(11)20-15/h1-4,9-10,12,15,17-19H,5-7H2
PubChem CID	430245
ChEMBL	N/A
IUPHAR	N/A
BindingDB	85329
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	16.3 nM	PMID9686407	BindingDB

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