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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Neurotensin receptor type 2
Species	Homo sapiens (Human)
Gene	NTSR2
Synonym	levocabastine-sensitive neurotensin receptor neurotensin receptor type 2 high-affinity levocabastine-sensitive neurotensin receptor NT2R NTR2 NTRL NTS2 receptor NT-R-2 [ Show all ]
Disease	N/A
Length	410
Amino acid sequence	METSSPRPPRPSSNPGLSLDARLGVDTRLWAKVLFTALYALIWALGAAGNALSAHVVLKARAGRAGRLRHHVLSLALAGLLLLLVGVPVELYSFVWFHYPWVFGDLGCRGYYFVHELCAYATVLSVAGLSAERCLAVCQPLRARSLLTPRRTRWLVALSWAASLGLALPMAVIMGQKHELETADGEPEPASRVCTVLVSRTALQVFIQVNVLVSFVLPLALTAFLNGVTVSHLLALCSQVPSTSTPGSSTPSRLELLSEEGLLSFIVWKKTFIQGGQVSLVRHKDVRRIRSLQRSVQVLRAIVVMYVICWLPYHARRLMYCYVPDDAWTDPLYNFYHYFYMVTNTLFYVSSAVTPLLYNAVSSSFRKLFLEAVSSLCGEHHPMKRLPPKPQSPTLMDTASGFGDPPETRT
UniProt	O95665
Protein Data Bank	N/A
GPCR-HGmod model	O95665
3D structure model	This predicted structure model is from GPCR-EXP O95665.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2514
IUPHAR	310
DrugBank	N/A

Ligand

Name	CHEMBL2431134
Molecular formula	C26H26N4O2
IUPAC name	6,7-dimethoxy-2-phenyl-4-(4-phenylpiperazin-1-yl)quinazoline
Molecular weight	426.52
Hydrogen bond acceptor	6
Hydrogen bond donor	0
XlogP	5.2
Synonyms	488725-39-9 MCULE-5431182931 AC1LZKTC SCHEMBL15819480 MLS-0454790.0001 AKOS022115923 STL333910 6,7-dimethoxy-2-phenyl-4-(4-phenylpiperazin-1-yl)quinazoline MolPort-000-810-051 BDBM50440747 ZINC2338076 [ Show all ]
Inchi Key	OPQWCRILQBQTND-UHFFFAOYSA-N
Inchi ID	InChI=1S/C26H26N4O2/c1-31-23-17-21-22(18-24(23)32-2)27-25(19-9-5-3-6-10-19)28-26(21)30-15-13-29(14-16-30)20-11-7-4-8-12-20/h3-12,17-18H,13-16H2,1-2H3
PubChem CID	1951822
ChEMBL	CHEMBL2431134
IUPHAR	N/A
BindingDB	50440747
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<80000.0 nM	PMID24611085	ChEMBL

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