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Name | Histamine H4 receptor |
---|---|
Species | Homo sapiens (Human) |
Gene | HRH4 |
Synonym | Pfi-013 SP9144 HH4R H4R H4 receptor [ Show all ] |
Disease | Allergic rhinitis Asthma Inflammatory disease Rheumatoid arthritis |
Length | 390 |
Amino acid sequence | MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS |
UniProt | Q9H3N8 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q9H3N8 |
3D structure model | This predicted structure model is from GPCR-EXP Q9H3N8. |
BioLiP | N/A |
Therapeutic Target Database | T26500 |
ChEMBL | CHEMBL3759 |
IUPHAR | 265 |
DrugBank | BE0000146 |
Name | CHEMBL495280 |
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Molecular formula | C16H19N7 |
IUPAC name | 4-(benzimidazol-1-yl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine |
Molecular weight | 309.377 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 1 |
XlogP | 1.6 |
Synonyms | SCHEMBL2167626 |
Inchi Key | ORASKGHXIUEBCT-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C16H19N7/c1-21-6-8-22(9-7-21)14-10-15(20-16(17)19-14)23-11-18-12-4-2-3-5-13(12)23/h2-5,10-11H,6-9H2,1H3,(H2,17,19,20) |
PubChem CID | 25130231 |
ChEMBL | CHEMBL495280 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 177.83 nM | PMID18811133 | ChEMBL |
Efficacy | 82.0 % | PMID18811133 | ChEMBL |
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