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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 2A
Species	Sus scrofa (Pig)
Gene	HTR2A
Synonym	5-HT-2 5-HT-2A 5-HT2A Serotonin receptor 2A
Disease	N/A for non-human GPCRs
Length	470
Amino acid sequence	MDVLCEENTSLSSPTNSFMQLNDDTRLYHNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPPCFSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHRRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQTGQKENSKQDDKATENDCTMVALGKQHSEDAPADNSNTVNEKVSCV
UniProt	P50129
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2490
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL1923293
Molecular formula	C20H23FN2O3
IUPAC name	1-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-[(4-fluoro-3-methoxyphenyl)methyl]piperazine
Molecular weight	358.413
Hydrogen bond acceptor	6
Hydrogen bond donor	0
XlogP	3.1
Synonyms	BDBM50358839
Inchi Key	OSBMHRHGAFUBCG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H23FN2O3/c1-24-19-12-15(2-4-17(19)21)14-22-6-8-23(9-7-22)16-3-5-18-20(13-16)26-11-10-25-18/h2-5,12-13H,6-11,14H2,1H3
PubChem CID	56926585
ChEMBL	CHEMBL1923293
IUPHAR	N/A
BindingDB	50358839
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	4200.0 nM	PMID22039961	BindingDB,ChEMBL

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