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GPCR

NameMelanin-concentrating hormone receptor 1
SpeciesMus musculus (Mouse)
GeneMchr1
SynonymSLC-1 {ECO:0000303|PubMed:11159839}
MCHR-1
MCHR
MCH1R
MCH1 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length353
Amino acid sequenceMDLQASLLSTGPNASNISDGQDNFTLAGPPPRTRSVSYINIIMPSVFGTICLLGIVGNSTVIFAVVKKSKLHWCSNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSMATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVKILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRTVSNAQTADEERTESKGT
UniProtQ8JZL2
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4730
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL205397
Molecular formulaC26H28ClFN4O2
IUPAC name3-(3-chloro-4-fluorophenyl)-1-[(1S,2R,5S)-5-(3-cyanophenyl)-2-bicyclo[3.1.0]hexanyl]-1-[2-[(3R)-3-hydroxypyrrolidin-1-yl]ethyl]urea
Molecular weight482.984
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP3.8
Synonyms(+)-N''-(3-chloro-4-fluorophenyl)-N-[trans-5-(3-cyanophenyl)bicyclo[3.1.0]h ex-2-yl]-N-[2-[3(R)-hydroxy-1-pyrrolidinyl]ethyl]urea
BDBM50184918
SCHEMBL14265830
(-)-N''-(3-chloro-4-fluorophenyl)-N-[trans-5-(3-cyanophenyl)bicyclo[3.1.0]hex-2-yl]-N-[2-[3(R)-hydroxy-1-pyrrolidinyl]ethyl]urea
Inchi KeyOSEWYJWQLIPRDD-LXRCUPKFSA-N
Inchi IDInChI=1S/C26H28ClFN4O2/c27-22-13-19(4-5-23(22)28)30-25(34)32(11-10-31-9-7-20(33)16-31)24-6-8-26(14-21(24)26)18-3-1-2-17(12-18)15-29/h1-5,12-13,20-21,24,33H,6-11,14,16H2,(H,30,34)/t20-,21-,24-,26-/m1/s1
PubChem CID10238912
ChEMBLCHEMBL205397
IUPHARN/A
BindingDB50184918
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Activity32.0 %PMID16570926ChEMBL
Activity57.0 %PMID16570926ChEMBL

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