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GPCR

NameD(1) dopamine receptor
SpeciesCarassius auratus (Goldfish)
Gene
SynonymDopamine D1 receptor
DiseaseN/A for non-human GPCRs
Length363
Amino acid sequenceMAVLDLNLTTVIDSGFMESDRSVRVLTGCFLSVLILSTLLGNTLVCAAVTKFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVTEVAGFWPFGAFCDIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPRVAFVMISGAWTLSVLISFIPVQLKWHKAQPIGFLEVNASRRDLPTDNCDSSLNRTYAISSSLISFYIPVAIMIVTYTQIYRIAQKQIRRISALERAAESAQIRHDSMGSGSNMDLESSFKLSFKRETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCKRTSNGLPCISPTTFDVFVWFGWANSSLNPIIYAFNADFRRAFAILLGCQRLCPGSISMETPSLNKN
UniProtP35406
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2368
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL2114444
Molecular formulaC17H19NO2S
IUPAC name(1S,10R)-15-ethyl-14-thia-11-azatetracyclo[8.7.0.02,7.013,17]heptadeca-2,4,6,13(17),15-pentaene-4,5-diol
Molecular weight301.404
Hydrogen bond acceptor4
Hydrogen bond donor3
XlogP3.1
SynonymsSCHEMBL7006451
2-Ethyl-4,5,5abeta,6,7,11balpha-hexahydro-3-thia-5-aza-3H-cyclopenta[c]phenanthrene-9,10-diol
CHEMBL2219803
BDBM50408146
Inchi KeyOXIMNPYYZPJDBV-DYVFJYSZSA-N
Inchi IDInChI=1S/C17H19NO2S/c1-2-10-6-12-16(21-10)8-18-13-4-3-9-5-14(19)15(20)7-11(9)17(12)13/h5-7,13,17-20H,2-4,8H2,1H3/t13-,17+/m1/s1
PubChem CID10662054
ChEMBLN/A
IUPHARN/A
BindingDB50408146
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC5022.0 nMPMID9171869BindingDB

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