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Name | Melanocortin receptor 4 |
---|---|
Species | Homo sapiens (Human) |
Gene | MC4R |
Synonym | MC4-R MC4 receptor |
Disease | Obesity; Sexual dysfunction Obesity; Diabetes Obesity Metabolic disorders Sexual dysfunction [ Show all ] |
Length | 332 |
Amino acid sequence | MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY |
UniProt | P32245 |
Protein Data Bank | N/A |
GPCR-HGmod model | P32245 |
3D structure model | This predicted structure model is from GPCR-EXP P32245. |
BioLiP | N/A |
Therapeutic Target Database | T72458 |
ChEMBL | CHEMBL259 |
IUPHAR | 285 |
DrugBank | N/A |
Name | CHEMBL2371833 |
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Molecular formula | C44H65N13O8 |
IUPAC name | (2S)-2-[[2-[[2-[[2-[acetyl(butyl)amino]acetyl]amino]acetyl]-(4-aminobutyl)amino]acetyl]amino]-N-[2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-2-oxoethyl]-N-[3-(diaminomethylideneamino)propyl]-3-phenylpropanamide |
Molecular weight | 904.087 |
Hydrogen bond acceptor | 10 |
Hydrogen bond donor | 9 |
XlogP | -1.2 |
Synonyms | BDBM50410250 CHEMBL190657 |
Inchi Key | BKCCPXJADVBUPG-ZPGRZCPFSA-N |
Inchi ID | InChI=1S/C44H65N13O8/c1-3-4-19-55(30(2)58)27-38(60)51-26-41(63)56(20-11-10-17-45)28-39(61)54-36(22-31-13-6-5-7-14-31)43(65)57(21-12-18-49-44(47)48)29-40(62)53-35(42(64)52-25-37(46)59)23-32-24-50-34-16-9-8-15-33(32)34/h5-9,13-16,24,35-36,50H,3-4,10-12,17-23,25-29,45H2,1-2H3,(H2,46,59)(H,51,60)(H,52,64)(H,53,62)(H,54,61)(H4,47,48,49)/t35-,36-/m0/s1 |
PubChem CID | 73353187 |
ChEMBL | CHEMBL2371833 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has more than 5 hydrogen bond donor. This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 3162.28 nM | PMID15974575 | ChEMBL |
IC50 | 5011.87 nM | PMID15974575 | ChEMBL |
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