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Name | P2Y purinoceptor 6 |
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Species | Homo sapiens (Human) |
Gene | P2RY6 |
Synonym | pyrimidinergic receptor P2Y P2Y6 receptor P2Y6 P2Y purinoceptor 6 P2Y ATP receptor 6 [ Show all ] |
Disease | N/A |
Length | 328 |
Amino acid sequence | MEWDNGTGQALGLPPTTCVYRENFKQLLLPPVYSAVLAAGLPLNICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDLSPPALATHYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQDGPAEPVAQERRGKAARMAVVVAAAFAISFLPFHITKTAYLAVRSTPGVPCTVLEAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRRPHELLQKLTAKWQRQGR |
UniProt | Q15077 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q15077 |
3D structure model | This predicted structure model is from GPCR-EXP Q15077. |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4714 |
IUPHAR | 326 |
DrugBank | N/A |
Name | CHEMBL507060 |
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Molecular formula | C10H16N2O11P2 |
IUPAC name | [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]methylphosphonic acid |
Molecular weight | 402.189 |
Hydrogen bond acceptor | 11 |
Hydrogen bond donor | 6 |
XlogP | -4.9 |
Synonyms | 44P GTPL1748 Uridine-5'-alpha,beta-methylene-diphosphate triethylammonium salt ((((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)methylphosphonic acid 5''-O-[(S)-HYDROXY(PHOSPHONOMETHYL)PHOSPHORYL]URIDINE [ Show all ] |
Inchi Key | PDEGDTTUBZXACY-ZOQUXTDFSA-N |
Inchi ID | InChI=1S/C10H16N2O11P2/c13-6-1-2-12(10(16)11-6)9-8(15)7(14)5(23-9)3-22-25(20,21)4-24(17,18)19/h1-2,5,7-9,14-15H,3-4H2,(H,20,21)(H,11,13,16)(H2,17,18,19)/t5-,7-,8-,9-/m1/s1 |
PubChem CID | 44585949 |
ChEMBL | CHEMBL507060 |
IUPHAR | 1748 |
BindingDB | 50271102 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 339.0 nM | PMID19902968 | BindingDB,ChEMBL |
EC50 | 660.0 nM | PMID18514530 | BindingDB,ChEMBL |
EC50 | 660.693 nM | PMID18514530 | IUPHAR |
EC50 | 700.0 nM | PMID20446735 | BindingDB,ChEMBL |
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