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Name | Mu-type opioid receptor |
---|---|
Species | Homo sapiens (Human) |
Gene | OPRM1 |
Synonym | hMOP M-OR-1 MOP opioid receptor, mu 1 opioid receptor [ Show all ] |
Disease | Diarrhea Inflammatory disease Pain Major depressive disorder Migraine [ Show all ] |
Length | 400 |
Amino acid sequence | MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP |
UniProt | P35372 |
Protein Data Bank | N/A |
GPCR-HGmod model | P35372 |
3D structure model | This predicted structure model is from GPCR-EXP P35372. |
BioLiP | N/A |
Therapeutic Target Database | T47768 |
ChEMBL | CHEMBL233 |
IUPHAR | 319 |
DrugBank | BE0000770 |
Name | CHEMBL322515 |
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Molecular formula | C27H28F3NO |
IUPAC name | 1-(3,3-diphenylpropyl)-4-[3-(trifluoromethyl)phenyl]piperidin-4-ol |
Molecular weight | 439.522 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 1 |
XlogP | 6.1 |
Synonyms | 1-(3,3-Diphenylpropyl)-4-[3-(trifluoromethyl)phenyl]piperidine-4-ol 1-(3,3-Diphenyl-propyl)-4-(3-trifluoromethyl-phenyl)-piperidin-4-ol BDBM50132647 |
Inchi Key | PDFCYCFNUWUGGU-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C27H28F3NO/c28-27(29,30)24-13-7-12-23(20-24)26(32)15-18-31(19-16-26)17-14-25(21-8-3-1-4-9-21)22-10-5-2-6-11-22/h1-13,20,25,32H,14-19H2 |
PubChem CID | 11743914 |
ChEMBL | CHEMBL322515 |
IUPHAR | N/A |
BindingDB | 50132647 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 1.0 nM | PMID12951102, PMID15454210 | BindingDB,ChEMBL |
Selectivity ratio | 0.01 - | PMID12951102 | ChEMBL |
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