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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Prostaglandin E2 receptor EP2 subtype
Species	Rattus norvegicus (Rat)
Gene	Ptger2
Synonym	EP2 receptor PGE receptor EP2 subtype PGE2 receptor EP2 subtype prostaglandin E receptor 2 (subtype EP2), 53kDa Prostanoid EP2 receptor Ptger-ep2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	357
Amino acid sequence	MDNSFNDSRRVENCESRQYLLSDESPAISSVMFTAGVLGNLIALALLARRWRGDTGCSAGSRTSISLFHVLVTELVLTDLLGTCLISPVVLASYSRNQTLVALAPESRACTYFAFTMTFFSLATMLMLFAMALERYLAIGHPYFYRRRVSRRGGLAVLPAIYGVSLLFCSLPLLNYGEYVQYCPGTWCFIQHGRTAYLQLYATVLLLLIVAVLGCNISVILNLIRMQLRSKRSRCGLSGSSLRGPGSRRRGERTSMAEETDHLILLAIMTITFAVCSLPFTIFAYMDETSSRKEKWDLRALRFLSVNSIIDPWVFVILRPPVLRLMRSVLCCRTSLRAPEAPGASCSTQQTDLCGQL
UniProt	Q62928
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4909
IUPHAR	341
DrugBank	N/A

Ligand

Name	CHEMBL562411
Molecular formula	C21H35NO5S
IUPAC name	7-[[4-(1-hydroxyhexyl)phenyl]methyl-methylsulfonylamino]heptanoic acid
Molecular weight	413.573
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	3.6
Synonyms	PEGKTVODCSBWQI-UHFFFAOYSA-N 7-(N-(4-(1-hydroxyhexyl)benzyl)methylsulfonamido)heptanoic acid SCHEMBL1471097 7-{[4-(1-hydroxy-hexyl)-benzyl]-methanesulfonyl-amino}-heptanoic acid BDBM50293498
Inchi Key	PEGKTVODCSBWQI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H35NO5S/c1-3-4-7-10-20(23)19-14-12-18(13-15-19)17-22(28(2,26)27)16-9-6-5-8-11-21(24)25/h12-15,20,23H,3-11,16-17H2,1-2H3,(H,24,25)
PubChem CID	10223499
ChEMBL	CHEMBL562411
IUPHAR	N/A
BindingDB	50293498
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	44.0 nM	PMID19250823	BindingDB,ChEMBL
IC50	93.0 nM	PMID19250823	BindingDB,ChEMBL

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