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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameP2Y purinoceptor 2
SpeciesHomo sapiens (Human)
GeneP2RY2
SynonymPurinergic receptor
purinergic receptor P2Y
P2Y2 receptor
P2Y2
P2Y purinoceptor 2
[ Show all ]
DiseaseDry eye disease
Constipation
Cystic fibrosis
Lung cancer
Length377
Amino acid sequenceMAADLGPWNDTINGTWDGDELGYRCRFNEDFKYVLLPVSYGVVCVPGLCLNAVALYIFLCRLKTWNASTTYMFHLAVSDALYAASLPLLVYYYARGDHWPFSTVLCKLVRFLFYTNLYCSILFLTCISVHRCLGVLRPLRSLRWGRARYARRVAGAVWVLVLACQAPVLYFVTTSARGGRVTCHDTSAPELFSRFVAYSSVMLGLLFAVPFAVILVCYVLMARRLLKPAYGTSGGLPRAKRKSVRTIAVVLAVFALCFLPFHVTRTLYYSFRSLDLSCHTLNAINMAYKVTRPLASANSCLDPVLYFLAGQRLVRFARDAKPPTGPSPATPARRRLGLRRSDRTDMQRIEDVLGSSEDSRRTESTPAGSENTKDIRL
UniProtP41231
Protein Data BankN/A
GPCR-HGmod modelP41231
3D structure modelThis predicted structure model is from GPCR-EXP P41231.
BioLiPN/A
Therapeutic Target DatabaseT93515
ChEMBLCHEMBL4398
IUPHAR324
DrugBankBE0002401

Ligand

Nameuridine 5'-triphosphate
Molecular formulaC9H15N2O15P3
IUPAC name[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
Molecular weight484.139
Hydrogen bond acceptor15
Hydrogen bond donor7
XlogP-5.8
Synonymsuridine triphosphate
63-39-8
Uteplex
UTP
5'-UTP
[ Show all ]
Inchi KeyPGAVKCOVUIYSFO-XVFCMESISA-N
Inchi IDInChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
PubChem CID6133
ChEMBLCHEMBL336296
IUPHAR1734
BindingDB50118213
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.

Experimental Data

ParameterValueReferenceDatabase source
EC50<300000.0 nMPMID19419204ChEMBL
EC507.0 nMPMID17079144, PMID17011188BindingDB,ChEMBL
EC507.94328 nMPMID8564228, PMID11754592IUPHAR
EC5017.9 nMPMID21417463ChEMBL
EC5018.0 nMPMID21417463BindingDB
EC5020.0 nMPMID22386981BindingDB,ChEMBL
EC5030.0 nMPMID11206448BindingDB,ChEMBL
EC5037.2 nMPMID19419204ChEMBL
EC5043.0 nMPMID17125260BindingDB,ChEMBL
EC5049.0 nMPMID17302398BindingDB,ChEMBL
EC5050.1 nMPMID19419204ChEMBL
EC5055.0 nMPMID21528910BindingDB,ChEMBL
EC5059.0 nMPMID19419204BindingDB,ChEMBL
EC5060.0 nMPMID21528910, PMID20446735, PMID18514530BindingDB,ChEMBL
EC5080.4 nMPMID19419204BindingDB,ChEMBL
EC50100.0 nMPMID20095577BindingDB,ChEMBL
EC50108.0 nMPMID19419204ChEMBL
EC50109.65 nMPMID17941622ChEMBL
EC50121.0 nMPMID19419204ChEMBL
EC50124.0 nMPMID19419204ChEMBL
EC50138.0 nMPMID19419204ChEMBL
EC50140.0 nMPMID12213051, PMID22901672BindingDB,ChEMBL
EC50157.0 nMPMID19419204ChEMBL
EC50450.0 nMPMID16539385BindingDB,ChEMBL
EC50640.0 nMPMID22107038, PMID18760862BindingDB,ChEMBL
EC50781.0 nMPMID19419204BindingDB,ChEMBL
EC502090.0 nMPMID19419204ChEMBL
EC5020600.0 nMPMID19419204ChEMBL
Efficacy3.0 %PMID19419204ChEMBL
Efficacy43.0 %PMID19419204ChEMBL
Efficacy86.0 %PMID19419204ChEMBL
Efficacy99.0 %PMID19419204ChEMBL
Efficacy100.0 %PMID19419204ChEMBL
Efficacy107.0 %PMID19419204ChEMBL
Efficacy109.0 %PMID19419204ChEMBL
Efficacy127.0 %PMID19419204ChEMBL
Efficacy128.0 %PMID19419204ChEMBL
Efficacy130.0 %PMID19419204ChEMBL
Efficacy133.0 %PMID19419204ChEMBL
Efficacy138.0 %PMID19419204ChEMBL
Ratio EC502.0 -PMID19419204ChEMBL
Ratio EC505.0 -PMID21528910ChEMBL
Ratio EC5025.0 -PMID19419204ChEMBL

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