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GPCR

Name	Mu-type opioid receptor
Species	Mus musculus (Mouse)
Gene	Oprm1
Synonym	opioid receptor, mu 1 opioid receptor OP3 Mu receptor MOR-1 MOPr MOP M-OR-1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	398
Amino acid sequence	MDSSAGPGNISDCSDPLAPASCSPAPGSWLNLSHVDGNQSDPCGPNRTGLGGSHSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGNILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSARIRQNTREHPSTANTVDRTNHQLENLEAETAPLP
UniProt	P42866
Protein Data Bank	4dkl, 5c1m, 6dde, 6ddf
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 4dkl.
BioLiP	BL0416752, BL0416751, BL0321492, BL0224753, BL0224754, BL0224755,BL0224756, BL0321491
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2858
IUPHAR	319
DrugBank	N/A

Ligand

Name	DSLET
Molecular formula	C33H46N6O10
IUPAC name	(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoic acid
Molecular weight	686.763
Hydrogen bond acceptor	11
Hydrogen bond donor	10
XlogP	-3.0
Synonyms	FT-0773267 Ser(2)-leu(5)-enkephalin-thr(6) (2S,5S,8S,14R,17S)-17-amino-8-benzyl-2-((R)-1-hydroxyethyl)-14-(hydroxymethyl)-18-(4-hydroxyphenyl)-5-isobutyl-4,7,10,13,16-pentaoxo-3,6,9,12,15-pentaazaoctadecan-1-oic acid AC1Q1O9T D0EM9A L-Threonine, L-tyrosyl-D-serylglycyl-L-phenylalanyl-L-leucyl- Tyrosyl-seryl-glycyl-phenylalanyl-leucyl-threonine 2-Ser-thr-leu-enkephalin C-54757 DSLET-OH Leucine-enkephalin, ser(2)-thr- [D-Ser2, Leu5, Thr6]-enkephalin 75644-90-5 Enkephalin-leu, ser(2)-thr- GTPL1609 Tyr-D-Ser-Gly-Phe-Leu-Thr (D-Ser2)-Leu-Enkephalin-Thr AKOS024456434 Dislet L-Threonine, N-(N-(N-(N-(N-L-tyrosyl-D-seryl)glycyl)-L-phenylalanyl)-L-leucyl)- tyrosyl-seryl-glycyl-phenylalanyl-leucyl-threonine, (L-Thr-D-Tyr-L-Ser-L-Phe-L-Leu)-isomer 2-{2-[2-(2-{2-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-3-hydroxy-propionylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoylamino}-3-hydroxy-butyric acid C20165 DSTLE LS-177202 [D-Ser2,Leu5]Enkephalin-Thr6 (2S,3R)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoic acid AC1L32UT CHEMBL124283 Enkephalin-leu, seryl(2)-threonine- H-Tyr-D-Ser-Gly-Phe-Leu-Thr-OH Tyr-ser-gly-phe-leu-thr BDBM50018708 Leu-enkephalin, ser(2)-thr- ZINC27215004 C33H46N6O10 Enkephalin, Ser(2), Leu(5), Thr(6)- [ Show all ]
Inchi Key	PKSODCLCMBUCPW-LVNBQDLPSA-N
Inchi ID	InChI=1S/C33H46N6O10/c1-18(2)13-24(32(47)39-28(19(3)41)33(48)49)37-31(46)25(15-20-7-5-4-6-8-20)36-27(43)16-35-30(45)26(17-40)38-29(44)23(34)14-21-9-11-22(42)12-10-21/h4-12,18-19,23-26,28,40-42H,13-17,34H2,1-3H3,(H,35,45)(H,36,43)(H,37,46)(H,38,44)(H,39,47)(H,48,49)/t19-,23+,24+,25+,26-,28+/m1/s1
PubChem CID	107847
ChEMBL	CHEMBL124283
IUPHAR	1609
BindingDB	50018708
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Ki	10.8 nM	PMID9694962	BindingDB
Ki	20.0 nM	PMID9694962	BindingDB

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