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GPCR

NameGlucagon receptor
SpeciesRattus norvegicus (Rat)
GeneGcgr
SynonymGGR
GL-R
glucagon receptor
GR
DiseaseN/A for non-human GPCRs
Length485
Amino acid sequenceMLLTQLHCPYLLLLLVVLSCLPKAPSAQVMDFLFEKWKLYSDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPPNTTANISCPWYLPWYHKVQHRLVFKRCGPDGQWVRGPRGQSWRDASQCQMDDDEIEVQKGVAKMYSSYQVMYTVGYSLSLGALLLALVILLGLRKLHCTRNYIHGNLFASFVLKAGSVLVIDWLLKTRYSQKIGDDLSVSVWLSDGAVAGCRVATVIMQYGIIANYCWLLVEGVYLYSLLSITTFSEKSFFSLYLCIGWGSPLLFVIPWVVVKCLFENVQCWTSNDNMGFWWILRIPVLLAILINFFIFVRIIHLLVAKLRAHQMHYADYKFRLARSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSTKLFFDLFFSSFQGLLVAVLYCFLNKEVQAELLRRWRRWQEGKALQEERMASSHGSHMAPAGTCHGDPCEKLQLMSAGSSSGTGCEPSAKTSLASSLPRLADSPT
UniProtP30082
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4720
IUPHAR251
DrugBankN/A

Ligand

NameCID 44336110
Molecular formulaC154H225N41O48S
IUPAC name(3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3R)-2-[[2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-amino-3-(1H-imidazol-4-yl)propanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]acetyl]amino]-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]amino]-4-[[(2S)-1-[[(2S,5S,8S,11S,20S)-11-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-4-amino-1-[[(1S,2R)-1-carboxy-2-hydroxypropyl]amino]-1,4-dioxobutan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamoyl]-8-(3-amino-3-oxopropyl)-2-[3-(diaminomethylideneamino)propyl]-5-methyl-3,6,9,14,21-pentaoxo-1,4,7,10,15-pentazacyclohenicos-20-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-oxobutanoic acid
Molecular weight3450.79
Hydrogen bond acceptor53
Hydrogen bond donor51
XlogP-15.4
SynonymsN/A
Inchi KeyPPGVJZANIZMGNQ-DUHXXKDWSA-N
Inchi IDInChI=1S/C154H225N41O48S/c1-74(2)55-100(136(225)176-99(50-54-244-11)135(224)184-107(63-117(160)208)145(234)195-125(80(10)202)153(242)243)179-140(229)106(61-85-66-166-91-30-19-18-29-89(85)91)183-133(222)97(44-48-116(159)207)177-150(239)122(76(5)6)193-143(232)104(57-81-25-14-12-15-26-81)181-134(223)98-45-49-118(209)164-52-23-21-32-93(130(219)171-94(33-24-53-165-154(161)162)129(218)169-77(7)126(215)170-96(132(221)175-98)43-47-115(158)206)173-148(237)112(71-198)190-142(231)109(65-121(213)214)185-137(226)101(56-75(3)4)178-138(227)102(59-83-34-38-87(203)39-35-83)180-131(220)92(31-20-22-51-155)172-147(236)111(70-197)189-139(228)103(60-84-36-40-88(204)41-37-84)182-141(230)108(64-120(211)212)186-149(238)113(72-199)191-152(241)124(79(9)201)194-144(233)105(58-82-27-16-13-17-28-82)187-151(240)123(78(8)200)192-119(210)68-167-128(217)95(42-46-114(157)205)174-146(235)110(69-196)188-127(216)90(156)62-86-67-163-73-168-86/h12-19,25-30,34-41,66-67,73-80,90,92-113,122-125,166,196-204H,20-24,31-33,42-65,68-72,155-156H2,1-11H3,(H2,157,205)(H2,158,206)(H2,159,207)(H2,160,208)(H,163,168)(H,164,209)(H,167,217)(H,169,218)(H,170,215)(H,171,219)(H,172,236)(H,173,237)(H,174,235)(H,175,221)(H,176,225)(H,177,239)(H,178,227)(H,179,229)(H,180,220)(H,181,223)(H,182,230)(H,183,222)(H,184,224)(H,185,226)(H,186,238)(H,187,240)(H,188,216)(H,189,228)(H,190,231)(H,191,241)(H,192,210)(H,193,232)(H,194,233)(H,195,234)(H,211,212)(H,213,214)(H,242,243)(H4,161,162,165)/t77-,78+,79+,80+,90-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,122-,123-,124-,125-/m0/s1
PubChem CID44336110
ChEMBLCHEMBL412488
IUPHARN/A
BindingDB50104040
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Activity630.0 %PMID11543679ChEMBL
IC500.24 nMPMID11543679BindingDB,ChEMBL

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