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GPCR

NamefMet-Leu-Phe receptor
SpeciesHomo sapiens (Human)
GeneFPR1
SynonymNFPR
N-formylpeptide chemoattractant receptor
N-formyl peptide receptor
FPR1
FPR
[ Show all ]
DiseaseInflammatory disease
Peptic ulcer
Length350
Amino acid sequenceMETNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
UniProtP21462
Protein Data BankN/A
GPCR-HGmod modelP21462
3D structure modelThis predicted structure model is from GPCR-EXP P21462.
BioLiPN/A
Therapeutic Target DatabaseT87831
ChEMBLCHEMBL3359
IUPHAR222
DrugBankBE0000995

Ligand

Name59880-97-6
Molecular formulaC21H31N3O5S
IUPAC name(2S)-2-[[(2S)-2-[[(2S)-2-formamido-4-methylsulfanylbutanoyl]amino]-4-methylpentanoyl]amino]-3-phenylpropanoic acid
Molecular weight437.555
Hydrogen bond acceptor6
Hydrogen bond donor4
XlogP1.5
SynonymsD0XF0A
For-Met-Leu-Phe-OH
KS-000019CN
N-Formyl-L-methionyl-L-leucyl-L-phenylalanine
SCHEMBL39529
[ Show all ]
Inchi KeyPRQROPMIIGLWRP-BZSNNMDCSA-N
Inchi IDInChI=1S/C21H31N3O5S/c1-14(2)11-17(23-19(26)16(22-13-25)9-10-30-3)20(27)24-18(21(28)29)12-15-7-5-4-6-8-15/h4-8,13-14,16-18H,9-12H2,1-3H3,(H,22,25)(H,23,26)(H,24,27)(H,28,29)/t16-,17-,18-/m0/s1
PubChem CID443295
ChEMBLCHEMBL267179
IUPHAR1022
BindingDB50050937
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC500.0630957 - 0.0794328 nMPMID1262785, PMID7387981IUPHAR
EC5010.0 nMPMID19639995BindingDB,ChEMBL
EC5020.0 nMPMID8676333BindingDB,ChEMBL
IC5020.0 nMPMID8676333BindingDB,ChEMBL
Kd3.0 nMPMID25587631ChEMBL
Kd3.0 nMPMID25587631BindingDB
Ki42.0 nMPMID17475488BindingDB,ChEMBL

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