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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Probable G-protein coupled receptor 142
Species	Homo sapiens (Human)
Gene	GPR142
Synonym	AXOR103 G-protein coupled receptor PGR2 GPR142 KIF19
Disease	N/A
Length	462
Amino acid sequence	MSIMMLPMEQKIQWVPTSLQDITAVLGTEAYTEEDKSMVSHAQKSQHSCLSHSRWLRSPQVTGGSWDLRIRPSKDSSSFRQAQCLRKDPGANNHLESQGVRGTAGDADRELRGPSEKATAGQPRVTLLPTPHVSGLSQEFESHWPEIAERSPCVAGVIPVIYYSVLLGLGLPVSLLTAVALARLATRTRRPSYYYLLALTASDIIIQVVIVFAGFLLQGAVLARQVPQAVVRTANILEFAANHASVWIAILLTVDRYTALCHPLHHRAASSPGRTRRAIAAVLSAALLTGIPFYWWLDMWRDTDSPRTLDEVLKWAHCLTVYFIPCGVFLVTNSAIIHRLRRRGRSGLQPRVGKSTAILLGITTLFTLLWAPRVFVMLYHMYVAPVHRDWRVHLALDVANMVAMLHTAANFGLYCFVSKTFRATVRQVIHDAYLPCTLASQPEGMAAKPVMEPPGLPTGAEV
UniProt	Q7Z601
Protein Data Bank	N/A
GPCR-HGmod model	Q7Z601
3D structure model	This predicted structure model is from GPCR-EXP Q7Z601.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2069161
IUPHAR	132
DrugBank	N/A

Ligand

Name	CHEMBL2409014
Molecular formula	C23H25N7O3S
IUPAC name	2-[5-[[[5-butyl-1-(5-methyl-4-thiophen-2-ylpyrimidin-2-yl)pyrazole-4-carbonyl]amino]methyl]imidazol-1-yl]acetic acid
Molecular weight	479.559
Hydrogen bond acceptor	8
Hydrogen bond donor	2
XlogP	2.6
Synonyms	BDBM50437420 SCHEMBL2394766
Inchi Key	PSBCZUNMLKUTRI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H25N7O3S/c1-3-4-6-18-17(22(33)25-11-16-10-24-14-29(16)13-20(31)32)12-27-30(18)23-26-9-15(2)21(28-23)19-7-5-8-34-19/h5,7-10,12,14H,3-4,6,11,13H2,1-2H3,(H,25,33)(H,31,32)
PubChem CID	67391041
ChEMBL	CHEMBL2409014
IUPHAR	N/A
BindingDB	50437420
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	0.2 nM	PMID24900747	ChEMBL
EC50	0.2 nM	PMID24900747	BindingDB

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