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GLASS

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GPCR

Name	Type-2 angiotensin II receptor
Species	Homo sapiens (Human)
Gene	AGTR2
Synonym	AT2 MRX88 Agtr2 angiotensin II receptor angiotensin II receptor, type 2 angiotensin II type 2 receptor Angiotensin II type-2 receptor AT2 receptor angiotensin receptor 2 AT2R AT2-R [ Show all ]
Disease	Postherpetic neuralgia Hypertension
Length	363
Amino acid sequence	MKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHLDAIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSCRKSSSLREMETFVS
UniProt	P50052
Protein Data Bank	5xjm, 5unh, 5ung, 5unf
GPCR-HGmod model	P50052
3D structure model	This structure is from PDB ID 5xjm.
BioLiP	BL0419199, BL0375199,BL0375200, BL0375198, BL0375196,BL0375197
Therapeutic Target Database	T09909
ChEMBL	CHEMBL4607
IUPHAR	35
DrugBank	BE0003426

Ligand

Name	losartan
Molecular formula	C22H23ClN6O
IUPAC name	[2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol
Molecular weight	422.917
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	4.3
Synonyms	54244-EP2298779A1 Lortaan 798L264 LS-78746 AKOS015994740 NCGC00095125-02 BIDD:GT0286 PSIFNNKUMBGKDQ-UHFFFAOYSA-N CCG-39095 D03AQG (1-((2'-(2h-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1h-imidazol-5-yl)methanol DTXSID7023227 1H-Imidazole-5-methanol, 2-butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-(9CI) F2173-0506 2-butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)-biphenyl-4-yl)methyl]imidazole HSDB 7043 54244-EP2277879A1 KBio2_004761 SR-01000763170 [2-butyl-4-chloro-1-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-1H-imidazol-5-yl]methanol KBioGR_001611 54244-EP2301936A1 Losartan monopotassium salt AB0013723 MK-954 BCP27731 NSC-758699 BSPBio_002695 RT-013597 CL23623 (2-butyl-4-chloro-1-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol DuP-753 2-butyl-4-chloro-1-[p-(o-1H-tetrazol-5ylphenyl)benzyl]imidazole-5-methanol GTPL3941 2-n-butyl-4-chloro-5-hydroxymethyl-1-[[2'-(1H-tetrazol-5-yl)-biphenyl-4-yl]methyl]imidazole I14-9710 54244-EP2292620A2 Spectrum2_001677 STL419984 [2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-4-imidazolyl]methanol 54244-EP2298772A1 KS-5004 54244-EP2308839A1 Losartic AC1L1H3Q MolPort-006-167-607 BDBM82258 Oprea1_644635 CAS-114798-26-4 SCHEMBL60 CS-2116 (1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methanol DSSTox_GSID_23227 1H-Imidazole-5-methanol, 2-butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)(1,1'- biphenyl)-4-yl)methyl)- EC 601-329-8 2-butyl-4-chloro-1-[[2'-(2h-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1h-imidazole-5-methanol HMS2093E22 54244-EP2270011A1 Jsp001094 Spectrum5_001466 UNII-JMS50MPO89 [3H]losartan KBio2_007329 54244-EP2301923A1 MCULE-5204931675 AN-15301 NCGC00095125-03 BRD-K76205745-001-02-5 PubChem9176 CHEBI:6541 D08146 (2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol DuP 753 1H-imidazole-5-methanol, 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- FT-0631074 2-butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazole HY-17512 54244-EP2287165A2 SR-01000763170-3 [2-butyl-5-chloranyl-3-[[4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol KBioSS_002193 54244-EP2305219A1 LOSARTAN POTASSIUM AB01563296_01 MK954 BCP9000861 NSC758699 C07072 SBI-0206766.P001 Cozaar DB00678 114798-26-4 DUP-89 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl-1H-imidazole-5-methanol GTPL590 I497 54244-EP2295053A1 Spectrum3_000998 Tox21_111435 [2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol 54244-EP2298776A1 L000351 Losartic (TN) AKOS015917390 NCGC00095125-01 BG0556 Pharmakon1600-01504268 CAS_114798-26-4 SPBio_001893 CTK8E7663 (1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methanol DSSTox_RID_76933 1H-Imidazole-5-methanol, 2-butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- (9CI) Epitope ID:140137 2-butyl-4-chloro-5-(hydroxymethyl)-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]imidazole HMS3715L11 54244-EP2272841A1 KBio2_002193 Spectrum_001713 ZINC3873160 {2-Butyl-5-chloro-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazol-4-yl}-methanol KBio3_001915 54244-EP2301931A1 Losartan (INN) A803239 MFCD00865831 API0007066 NCGC00095125-05 BRD-K76205745-001-04-1 Q-201321 D0DD0K (2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-1H-imidazol-5-yl)methanol DUP 89 2-Butyl-4-chloro-1-((2'-(1H-etrazol-5-yl) (1,1'-biphenyl)-4-yl)methyl)-1H-imidazole-5-methanol GP6564 2-n-butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazole Hyzaar 54244-EP2287166A2 SPECTRUM1504268 SR-01000763170-4 [2-butyl-5-chloro-3-[[4-[2-(1H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol 54244-EP2295406A1 KS-00000GI2 54244-EP2308562A2 Losartan [INN:BAN] AB07507 MolPort-003-666-553 BCPP000183 NSC_3961 C22H23ClN6O SC-47229 Cozaar (TN) (1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methanol DSSTox_CID_3227 124750-99-8 (mono-potassium salt) Dup89 2-BUTYL-4-CHLORO-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1H-IMIDAZOLE-5-METHANOL HMS1922J13 54244-EP2269989A1 JMS50MPO89 Spectrum4_001126 Tox21_111435_1 [3H]-losartan [ Show all ]
Inchi Key	PSIFNNKUMBGKDQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)
PubChem CID	3961
ChEMBL	CHEMBL191
IUPHAR	3941, 590
BindingDB	82258
DrugBank	DB00678
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<10000.0 nM	PMID26810314, PMID22309912, PMID24007859, PMID15537354	BindingDB,ChEMBL
IC50	19.0 nM	PMID21413808	BindingDB,ChEMBL

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