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GPCR

NameD(3) dopamine receptor
SpeciesRattus norvegicus (Rat)
GeneDrd3
SynonymDopamine D3 receptor
D3 receptor
dopaminergic receptor D3
D3R
DiseaseN/A for non-human GPCRs
Length446
Amino acid sequenceMAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSICSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC
UniProtP19020
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3138
IUPHAR216
DrugBankN/A

Ligand

NameCHEMBL69562
Molecular formulaC19H28N2
IUPAC name1-methyl-N,N-dipropyl-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-amine
Molecular weight284.447
Hydrogen bond acceptor1
Hydrogen bond donor1
XlogP5.0
SynonymsBDBM50035310
1-Methyl-N,N-dipropyl-6,7,8,9-tetrahydro-3H-benz[e]indol-8-amine
(1-Methyl-6,7,8,9-tetrahydro-3H-benzo[e]indol-8-yl)-dipropyl-amine
Inchi KeyBLMNALZUWKHXKM-UHFFFAOYSA-N
Inchi IDInChI=1S/C19H28N2/c1-4-10-21(11-5-2)16-8-6-15-7-9-18-19(17(15)12-16)14(3)13-20-18/h7,9,13,16,20H,4-6,8,10-12H2,1-3H3
PubChem CID10356544
ChEMBLCHEMBL69562
IUPHARN/A
BindingDB50035310
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki67.0 nMPMID7783152BindingDB,ChEMBL

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