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GPCR

NameTrace amine-associated receptor 7b
SpeciesRattus norvegicus (Rat)
GeneTaar7b
SynonymTaR-12
Trace amine receptor 12
Trace amine receptor 7b
TaR-7b
DiseaseN/A for non-human GPCRs
Length358
Amino acid sequenceMATDDDRFPWDQDSILSRDLLSASSMQLCYEKLNRSCVRSPYSPGPRLILYAVFGFGAVLAVCGNLLVMTSILHFRQLHSPANFLVASLACADFLVGLTVMPFSMVRSVEGCWYFGDIYCKFHSSFDGSFCYSSIFHLCFISADRYIAVSDPLIYPTRFTASVSGKCITFSWLLSIIYSFSLFYTGVNEAGLEDLVSALTCVGGCQIAVNQSWVFINFLLFLVPALVMMTVYSKIFLIAKQQAQNIEKMGKQTARASESYKDRVAKRERKAAKTLGIAVAAFLLSWLPYFIDSIIDAFLGFVTPTYVYEILVWIGYYNSAMNPLIYAFFYPWFRKAIKLIVTGKILRENSSATNLFPE
UniProtQ923X8
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2176813
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3701919
Molecular formulaC18H22N2O2
IUPAC nameN-[(4-methoxyphenyl)methyl]-4-[(2S)-morpholin-2-yl]aniline
Molecular weight298.386
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP2.6
SynonymsSCHEMBL12610144
BDBM129378
US8802673, 20
Inchi KeyBLNVIMYBVSDGSQ-GOSISDBHSA-N
Inchi IDInChI=1S/C18H22N2O2/c1-21-17-8-2-14(3-9-17)12-20-16-6-4-15(5-7-16)18-13-19-10-11-22-18/h2-9,18-20H,10-13H2,1H3/t18-/m1/s1
PubChem CID68325799
ChEMBLCHEMBL3701919
IUPHARN/A
BindingDB129378
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki764.1 nM, NoneBindingDB,ChEMBL

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