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Name | Free fatty acid receptor 1 |
---|---|
Species | Mus musculus (Mouse) |
Gene | Ffar1 |
Synonym | FFA1 receptor FFA1R G protein-coupled receptor 40 G-protein coupled receptor 40 GPR40 |
Disease | N/A for non-human GPCRs |
Length | 300 |
Amino acid sequence | MDLPPQLSFALYVSAFALGFPLNLLAIRGAVSHAKLRLTPSLVYTLHLGCSDLLLAITLPLKAVEALASGAWPLPLPFCPVFALAHFAPLYAGGGFLAALSAGRYLGAAFPFGYQAIRRPRYSWGVCVAIWALVLCHLGLALGLETSGSWLDNSTSSLGINIPVNGSPVCLEAWDPDSARPARLSFSILLFFLPLVITAFCYVGCLRALVRSGLSHKRKLRAAWVAGGALLTLLLCLGPYNASNVASFINPDLGGSWRKLGLITGAWSVVLNPLVTGYLGTGPGRGTICVTRTQRGTIQK |
UniProt | Q76JU9 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL5411 |
IUPHAR | N/A |
DrugBank | N/A |
Name | CHEMBL1777870 |
---|---|
Molecular formula | C21H20O3 |
IUPAC name | 3-[4-[[(1R)-2,3-dihydro-1H-inden-1-yl]oxy]phenyl]hex-4-ynoic acid |
Molecular weight | 320.388 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 1 |
XlogP | 4.2 |
Synonyms | BDBM50344077 3-(4-((R)-2,3-dihydro-1H-inden-1-yloxy)phenyl)hex-4-ynoic acid |
Inchi Key | PWKDPFKRLIKHTE-UUSAFJCLSA-N |
Inchi ID | InChI=1S/C21H20O3/c1-2-5-17(14-21(22)23)15-8-11-18(12-9-15)24-20-13-10-16-6-3-4-7-19(16)20/h3-4,6-9,11-12,17,20H,10,13-14H2,1H3,(H,22,23)/t17?,20-/m1/s1 |
PubChem CID | 54586486 |
ChEMBL | CHEMBL1777870 |
IUPHAR | N/A |
BindingDB | 50344077 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 47.0 nM | PMID21514824 | BindingDB,ChEMBL |
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